EP 0942979 A2 19990922 - IL-9 RECEPTOR VARIANTS, USEFUL IN TREATING AND DIAGNOSING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS
Title (en)
IL-9 RECEPTOR VARIANTS, USEFUL IN TREATING AND DIAGNOSING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS
Title (de)
BIOLOGISCHE VARIABILITÄT VON ASTHMA-ASSOZIIERTEM FAKTOR 2, AAF2 (IL-9 REZEPTOR) UND IHRE BEDEUTUNG FÜR DIE BEHANDLUNG UND DIAGNOSE VON ATOPISCHEN ALLERGIEN WIE ASTHMA UND ASTHMA-ÄHNLICHEN ERKRANKUNGEN
Title (fr)
VARIANTS DE RECEPTEUR IL-9, UTILISES POUR LE TRAITEMENT ET LE DIAGNOSTIC DES ALLERGIES ATOPIQUE, Y COMPRIS L'ASTHME ET LES TROUBLES APPARENTES
Publication
Application
Priority
- US 9721992 W 19971202
- US 3222496 P 19961202
- US 98087297 A 19971201
Abstract (en)
[origin: CA2271952A1] This invention relates to the diagnosis, treatment and methods for discovery of new therapeutics for atopic asthma and related disorders based on variants of Asthma Associated Factor (2). One embodiment of the invention is a variant of AAF2, wherein codon 173 is deleted resulting in the loss of glutamine 173 from the mature protein precursor. This single amino acid deletion results in a non-functional AAF2 protein and therefore the presence of this phenotype should be associated with less evidence of atopic asthma. Correspondingly, the lack of susceptibility to an asthmatic, atopic phenotype is characterized by the loss of glutamine at codon 173. The invention includes isolated DNA molecules which are variants of the wild type sequence as well as the proteins encoded by such DNA and the use of such DNA molecules and expressed protein in the diagnosis and treatment of atopic asthma.
IPC 1-7
C12N 15/12; C07K 14/715; C12Q 1/68; G01N 33/566; G01N 33/68; A61K 38/17; C12N 5/10; C12N 15/11
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61P 11/06 (2006.01); C07K 14/715 (2006.01); C12N 5/10 (2006.01); C12N 15/11 (2006.01); C12N 15/12 (2006.01); C12Q 1/68 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
C07K 14/7155 (2013.01 - EP); C12Q 1/6883 (2013.01 - EP US); A61K 38/00 (2013.01 - EP); C12Q 2600/156 (2013.01 - EP)
Citation (search report)
See references of WO 9824904A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
AT E471982 T1 20100715; AU 5689198 A 19980629; AU 746595 B2 20020502; CA 2271952 A1 19980611; CA 2271952 C 20100406; DE 69739920 D1 20100805; EP 0942979 A2 19990922; ES 2347962 T3 20101126; JP 2002514911 A 20020521; JP 2009159976 A 20090723; JP 4552076 B2 20100929; PT 1471144 E 20100817
DOCDB simple family (application)
AT 04013403 T 19971202; AU 5689198 A 19971202; CA 2271952 A 19971202; DE 69739920 T 19971202; EP 97953072 A 19971202; ES 04013403 T 19971202; JP 2009048597 A 20090302; JP 52573798 A 19971202; PT 04013403 T 19971202