EP 0943095 A2 19990922 - A WHOLE BLOOD/MITOGEN ASSAY FOR THE EARLY DETECTION OF A SUBJECT WITH CANCER AND KIT
Title (en)
A WHOLE BLOOD/MITOGEN ASSAY FOR THE EARLY DETECTION OF A SUBJECT WITH CANCER AND KIT
Title (de)
TESTVERFAHREN UND KIT ZUR FRÜHERKENNUNG VON KREBSPATIENTEN UNTER VERWENDUNG VON GANZEM BLUT UND MITOGENE
Title (fr)
PROCEDE ET TROUSSE DE DOSAGE DU SANG ENTIER ET DU FACTEUR MITOGENE SERVANT A EFFECTUER LA DETECTION PRECOCE DU CANCER CHEZ UN SUJET
Publication
Application
Priority
- IL 9700381 W 19971121
- US 75523296 A 19961122
- US 75524096 A 19961122
- US 75528796 A 19961122
- US 75541296 A 19961122
- US 75541396 A 19961122
- US 75541496 A 19961122
- US 75541596 A 19961122
Abstract (en)
[origin: WO9822825A2] This invention provides a method of detecting a subject having ovarian or breast cancer, comprising the following steps: a) obtaining a whole blood sample from the subject; b) incubating the whole blood sample in a culture in the presence of a media containing a mitogen with or without antigen, so as to induce polyclonal and specific activation of lymphocytic cells leading to antibody production; c) exposing the resultant culture of step b) to a specific tumor antigen, thereby allowing an antigen-antibody immune complex to form; d) detecting the antigen-antibody immune complex of step c); wherein the presence of tumor antigen associated antibody is indicative of the subject having the cancer.
IPC 1-7
IPC 8 full level
C12Q 1/68 (2006.01); G01N 33/53 (2006.01); G01N 33/574 (2006.01)
CPC (source: EP)
C12Q 1/6886 (2013.01); G01N 33/57415 (2013.01); G01N 33/57449 (2013.01); G01N 33/57488 (2013.01); G01N 33/5767 (2013.01); G01N 2800/52 (2013.01)
Citation (search report)
See references of WO 9822825A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9822825 A2 19980528; WO 9822825 A3 19980806; AU 5066098 A 19980610; CA 2272924 A1 19980528; EP 0943095 A2 19990922; IL 130074 A0 20000229; JP 2001504233 A 20010327
DOCDB simple family (application)
IL 9700381 W 19971121; AU 5066098 A 19971121; CA 2272924 A 19971121; EP 97913412 A 19971121; IL 13007497 A 19971121; JP 52342398 A 19971121