Global Patent Index - EP 0944388 A4

EP 0944388 A4 20010816 - INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (en)

INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (de)

HEMMERN VON FARNESYL PROTEIN TRANSFERASE

Title (fr)

INHIBITEURS DE LA FARNESYL-PROTEINE TRANSFERASE

Publication

EP 0944388 A4 20010816 (EN)

Application

EP 97921256 A 19970327

Priority

  • GB 9609981 A 19960513
  • US 9706487 W 19970327
  • US 1479196 P 19960403

Abstract (en)

[origin: WO9738665A2] The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

IPC 1-7

A61K 31/445; C07D 401/04; C07D 401/06; C07D 401/12

IPC 8 full level

A61K 31/445 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/4709 (2006.01); A61P 9/00 (2006.01); A61P 13/12 (2006.01); A61P 27/02 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 211/62 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01)

CPC (source: EP)

A61P 9/00 (2017.12); A61P 13/12 (2017.12); A61P 27/02 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 211/62 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 413/14 (2013.01)

Citation (search report)

  • [PY] WO 9610034 A2 19960404 - MERCK & CO INC [US], et al
  • [PY] WO 9630343 A1 19961003 - MERCK & CO INC [US], et al
  • [PY] WO 9609820 A1 19960404 - MERCK & CO INC [US], et al
  • [PY] WO 9637204 A1 19961128 - MERCK & CO INC [US], et al
  • [A] WO 9606609 A1 19960307 - MERCK & CO INC [US], et al
  • [A] WO 9500497 A1 19950105 - MERCK & CO INC [US], et al
  • [A] EP 0675112 A1 19951004 - BRISTOL MYERS SQUIBB CO [US]
  • [A] WILLIAMS,T. ET AL.: "2-Substituted Piperazines as Constrained Amino Acids. Application to the Synthesis of Potent, Non Carboxylic Acid Inhibitors of Farnesyltransferase", J.MED.CHEM., vol. 39, no. 7, 29 March 1996 (1996-03-29), WASHINGTON, pages 1345 - 1348, XP002169367
  • [A] GRAHAM,S.L.: "Inhibitors of protein farnesylation : a new approach to cancer chemotherapy", EXP.OPIN.THER.PATENTS, vol. 5, no. 12, 1995, LONDON, pages 1269 - 1285, XP001000610
  • See references of WO 9738665A2

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9738665 A2 19971023; WO 9738665 A3 19971127; AU 2734797 A 19971107; AU 715202 B2 20000120; CA 2249601 A1 19971023; EP 0944388 A2 19990929; EP 0944388 A4 20010816; JP 2001519766 A 20011023

DOCDB simple family (application)

US 9706487 W 19970327; AU 2734797 A 19970327; CA 2249601 A 19970327; EP 97921256 A 19970327; JP 53738897 A 19970327