Global Patent Index - EP 0944394 A4

EP 0944394 A4 20030514 - TREATMENT OF HIV-INFECTION BY INTERFERING WITH HOST CELL CYCLOPHILIN RECEPTOR ACTIVITY

Title (en)

TREATMENT OF HIV-INFECTION BY INTERFERING WITH HOST CELL CYCLOPHILIN RECEPTOR ACTIVITY

Title (de)

BEHANDLUNG EINER HIV-INFEKTION DURCH BEEINTRÄCHTIGUNG DER CYCLOPHILINREZEPTOR-AKTIVITÄT INNERHALB DER WIRTSZELLE

Title (fr)

TRAITEMENT DE L'INFECTION A VIH PAR ACTION SUR LE RECEPTEUR DE LA CYCLOPHILINE DE CELLULES HOTES

Publication

EP 0944394 A4 20030514 (EN)

Application

EP 97917517 A 19970312

Priority

  • US 9703819 W 19970312
  • US 1318596 P 19960312
  • US 61593396 A 19960314

Abstract (en)

[origin: WO9733604A1] There is disclosed pharmaceutical compositions for the treatment of HIV-infection using cyclophilin A and its corresponding human cellular binding partner as a target for intervention. There is further disclosed a method of using cyclophilins, anti-cyclophilin antibodies, and pegylated cyclosporin A as a treatment for HIV-infection. The present invention further provides screening assays for the identification of compounds which inhibit the interaction of cyclophilin and its cellular receptor.

IPC 1-7

A61K 38/13; A61K 39/395; A61K 39/39; C12N 9/90; A61K 47/48

IPC 8 full level

A61K 47/48 (2006.01); A61K 31/00 (2006.01); A61K 38/00 (2006.01); A61K 38/13 (2006.01); A61K 38/52 (2006.01); A61K 39/00 (2006.01); A61K 39/385 (2006.01); A61K 39/39 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61P 31/00 (2006.01); A61P 31/18 (2006.01); C07K 16/40 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/566 (2006.01)

CPC (source: EP)

A61K 38/13 (2013.01); A61K 38/52 (2013.01); A61P 31/00 (2017.12); A61P 31/18 (2017.12); C07K 16/40 (2013.01)

Citation (search report)

  • [Y] WO 9323081 A1 19931125 - UNIV ROCKEFELLER [US], et al
  • [Y] EP 0484281 A2 19920506 - SANDOZ LTD [CH], et al
  • [Y] WO 9507468 A1 19950316 - SANDOZ LTD [CH], et al
  • [Y] ROYDON PRICE E ET AL: "CYCLOPHILIN B TRAFFICKING THROUGH THE SECRETORY PATHWAY IS ALTERED BY BINDING OF CYCLOSPORIN A", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 91, April 1994 (1994-04-01), pages 3931 - 3935, XP002931337, ISSN: 0027-8424
  • [Y] ALLAIN F ET AL: "Selective assay for CyPA and CyPB in human blood using highly specific anti-peptide antibodies", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 178, no. 1, 13 January 1995 (1995-01-13), pages 113 - 120, XP004021130, ISSN: 0022-1759
  • [Y] BILLICH A ET AL: "MODE OF ACTION OF SDZ NIM 811, A NONIMMUNOSUPPRESSIVE CYCLOSPORIN A ANALOG WITH ACTIVITY AGAINST HUMAN IMMUNODEFICIENCY VIRUS (HIV) TYPE 1: INTERFERENCE WITH HIV PROTEIN-CYCLOPHILIN A INTERACTIONS", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 69, no. 4, 1 April 1995 (1995-04-01), pages 2451 - 2461, XP002022423, ISSN: 0022-538X
  • See references of WO 9733604A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9733604 A1 19970918; AU 2581197 A 19971001; AU 723905 B2 20000907; CA 2248192 A1 19970918; EP 0944394 A1 19990929; EP 0944394 A4 20030514; JP 2000510097 A 20000808

DOCDB simple family (application)

US 9703819 W 19970312; AU 2581197 A 19970312; CA 2248192 A 19970312; EP 97917517 A 19970312; JP 53277397 A 19970312