EP 0945893 A3 20060412 - Method of mass-analyzing body fluid and apparatus therefor
Title (en)
Method of mass-analyzing body fluid and apparatus therefor
Title (de)
Verfahren zur Massenanalyse von Körperflussigkeiten and Vorrichtung dazu
Title (fr)
Méthode d'analyse de fluides corporels par détermination de la masse et dispositif associé
Publication
Application
Priority
JP 7760498 A 19980325
Abstract (en)
[origin: EP0945893A2] Toward a living body fluid, i.e. an analyte solution in which substances contained vary with a lapse of time and which has an extremely high electrical conductivity, it is an object of the present invention to allow the ionization thereof to be performed effectively, thus making it possible to mass-analyze the analyte solution in a short while. In order to accomplish the above-described object, there is provided an ionization source in which the following process is executed: The analyte solution, i.e. a mixture solution with a physiological saline containing the living body substances, is introduced from a living body 5 into a capillary 9 without being separated. Then, gas is caused to pass through an orifice 10, which is located coaxially with the capillary 9 and into which a tip of the capillary 9 is inserted, at the sonic velocity or at a high velocity close thereto, thereby spraying and ionizing the analyte solution at the tip of the capillary 9. Moreover, there is provided an ion trap mass spectrometer (3DQMS) 12 for mass-analyzing the ions from the ionization source, thereby mass-analyzing the analyte solution at a time. As a result, it has become possible to perform a mass analysis of the living body substances, in particular, neurotransmitters in a state in which they really are in the living body 5, although, conventionally, it was impossible to perform such type of mass analysis. It has also become possible to perform a mass analysis in response to a change of the living body 5 while directly collecting a cerebral spinal fluid from the brain.
IPC 8 full level
A61B 5/00 (2006.01); G01N 1/10 (2006.01); G01N 1/28 (2006.01); G01N 27/62 (2006.01); G01N 30/72 (2006.01); H01J 49/04 (2006.01)
CPC (source: EP US)
A61B 5/145 (2013.01 - EP US); A61B 5/14528 (2013.01 - EP US); A61B 5/14557 (2013.01 - EP US); A61B 5/1459 (2013.01 - EP US); A61B 5/4064 (2013.01 - EP US); H01J 49/0431 (2013.01 - EP US); A61B 2010/0077 (2013.01 - EP US)
Citation (search report)
- [Y] EP 0762473 A2 19970312 - HITACHI LTD [JP]
- [A] US 5572023 A 19961105 - CAPRIOLI RICHARD M [US]
- [A] US 5078135 A 19920107 - CAPRIOLI RICHARD M [US]
- [A] US 5015845 A 19910514 - ALLEN MARK [US], et al
- [AD] US 5130538 A 19920714 - FENN JOHN B [US], et al
- [Y] ATSUMU HIRABAYASHI ET AL.: "sonic spray mass spectrometry", ANAL.CHEM., vol. 67, no. 17, 1995, pages 2878 - 2882, XP002367774
- [A] ATSUMU HIRABAYASHI ET AL.: "sonic spray ionization method for atmospheric pressure ionization mass spectrometry", ANAL. CHEM., vol. 66, no. 24, 1994, pages 4557 - 4559, XP002367775
- [A] PATENT ABSTRACTS OF JAPAN vol. 1998, no. 05 30 April 1998 (1998-04-30)
- [AD] PATENT ABSTRACTS OF JAPAN vol. 1996, no. 03 29 March 1996 (1996-03-29)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
EP 0945893 A2 19990929; EP 0945893 A3 20060412; JP 3372862 B2 20030204; JP H11271277 A 19991005; US 6190316 B1 20010220; US 6478738 B1 20021112
DOCDB simple family (application)
EP 99105800 A 19990322; JP 7760498 A 19980325; US 27355499 A 19990322; US 69501900 A 20001025