Global Patent Index - EP 0946192 A1

EP 0946192 A1 19991006 - USES OF THIOREDOXIN

Title (en)

USES OF THIOREDOXIN

Title (de)

VERWENDUNG VON THIOREDOXIN

Title (fr)

UTILISATIONS DE THIOREDOXINE

Publication

EP 0946192 A1 19991006 (EN)

Application

EP 97952292 A 19971205

Priority

  • US 9722292 W 19971205
  • US 3199596 P 19961206

Abstract (en)

[origin: WO9824472A1] The present invention relates to the use of thioredoxin as, inter alia, a cell growth stimulator, as well as a screen for agents that are useful in reducing or preventing thioredoxin-associated apoptosis inhibition and agents that are useful in inhibiting thioredoxin stimulated cell growth.

IPC 1-7

A61K 38/44; A61K 48/00; C12Q 1/26; G01N 33/68

IPC 8 full level

A61K 38/44 (2006.01); G01N 33/50 (2006.01); A61K 48/00 (2006.01)

CPC (source: EP)

G01N 33/5011 (2013.01); A61K 48/00 (2013.01)

Citation (examination)

  • US 5118624 A 19920602 - PARRISH WAYNE B [US], et al
  • HOLMGREN A.: "Thioredoxin", ANN. REV. BIOCHEM., vol. 54, 1985, pages 237 - 272
  • REN X. ET AL: "Mutagenesis of structural half-cystine residues in human thioredoxin and effects on the regulation of activity by selenodiglutathione", BIOCHEMISTRY, vol. 32, 1993, pages 9701 - 9708
  • OBLONG J.E. ET AL: "Site-directed mutagenesis of active site cysteines in human thioredoxin produces competitive inhibitors of human thioredoxin reductase and elimination of mitogenic properties of thioredoxin", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 16, 1994, pages 11714 - 11720
  • OBLONG J.E. ET AL: "Reversible inhibition of human thioredoxin reductase activity by cytotoxic alkyl 2-imidazolyl disulfide analogues", CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 34, 1994, pages 434 - 438
  • BERGGREN M. ET AL: "Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia", ANTICANCER RESEARCH, vol. 16, 1996, pages 3459 - 3466
  • See also references of WO 9824472A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9824472 A1 19980611; CA 2274116 A1 19980611; CA 2274116 C 20090505; EP 0946192 A1 19991006

DOCDB simple family (application)

US 9722292 W 19971205; CA 2274116 A 19971205; EP 97952292 A 19971205