Title (en)

NEW AMIDE COMPOUNDS

Title (de)

AMINDVERBINDUNGEN UND IHRE VERWENDUNG ALS INHIBITOREN DER BITRIC-OXID-SYNTHASE

Title (fr)

NOUVEAUX COMPOSES AMIDE

Publication

EP 0946587 A2 19991006 (EN)

Application

EP 97912529 A 19971120

Priority

• AU PO421996 A 19961216
• AU PO592997 A 19970401
• AU PO903097 A 19970909
• JP 9704243 W 19971120

Abstract (en)

[origin: WO9827108A2] A compound of formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases such as adult respiratory distress syndrome, cardiovascular ischemia, myocarditis, heart failure, synovitis, shock, diabetes, diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, glomerulonephritis, peptic ulcer, inflammatory bowel disease, cerebral infarction, cerebral ischemia, cerebral hemorrhage, migraine, rheumatoid arthritis, gout, neuritis, postherpetic neuralgia, osteoarthritis, osteoporosis, systemic lupus erythematosus, rejection by organ transplantation, asthma, metastasis, Alzheimer's disease, arthritis, CNS disorders, dermatitis, hepatitis, liver cirrhosis, multiple sclerosis, pancreatitis, atherosclerosis, and the like in human being and animals.

IPC 1-7

C07K 5/00; C07D 403/00; C07D 401/00

IPC 8 full level

A61K 31/4164 (2006.01); A61K 31/4178 (2006.01); A61K 31/422 (2006.01); A61K 31/423 (2006.01); A61K 31/427 (2006.01); A61K 31/4439 (2006.01); A61K 31/4545 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/498 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61P 1/04 (2006.01); A61P 1/16 (2006.01); A61P 3/10 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01); A61P 13/12 (2006.01); A61P 17/00 (2006.01); A61P 19/02 (2006.01); A61P 19/06 (2006.01); A61P 19/10 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/28 (2006.01); A61P 27/00 (2006.01); A61P 29/00 (2006.01); A61P 35/04 (2006.01); A61P 43/00 (2006.01); C07D 233/54 (2006.01); C07D 233/64 (2006.01); C07D 233/90 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 521/00 (2006.01)

CPC (source: EP)

A61P 1/04 (2017.12); A61P 1/16 (2017.12); A61P 3/10 (2017.12); A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 13/12 (2017.12); A61P 17/00 (2017.12); A61P 19/02 (2017.12); A61P 19/06 (2017.12); A61P 19/10 (2017.12); A61P 25/00 (2017.12); A61P 25/04 (2017.12); A61P 25/28 (2017.12); A61P 27/00 (2017.12); A61P 29/00 (2017.12); A61P 35/04 (2017.12); A61P 43/00 (2017.12); C07D 231/12 (2013.01); C07D 233/56 (2013.01); C07D 233/64 (2013.01); C07D 233/90 (2013.01); C07D 249/08 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01)

Citation (search report)

See references of WO 9827108A2

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9827108 A2 19980625; WO 9827108 A3 19980730; EP 0946587 A2 19991006; JP 2001505585 A 20010424

DOCDB simple family (application)

JP 9704243 W 19971120; EP 97912529 A 19971120; JP 52752898 A 19971120