Title (en)

HSV/AAV HYBRID AMPLICON VECTORS

Title (de)

HSV/AAV HYBRID-AMPLICON-VEKTOREN

Title (fr)

VECTEURS AMPLICONS HYBRIDES DU VIRUS DE L'HERPES SIMPLEX (HSV) ET DE VIRUS ADENO-ASSOCIES (AAV)

Publication

EP 0946733 A4 20030108 (EN)

Application

EP 97946914 A 19971112

Priority

• US 9720422 W 19971112
• US 74791996 A 19961112

Abstract (en)

[origin: WO9821345A1] The present invention relates to a hybrid vector system which incorporates elements of herpesvirus and adeno-associated virus which are capable of expressing a gene product in eukaryotic cells. The vector system of the present invention provides a means of packaging plasmid DNA into highly infectious virions which can efficiently and safely deliver large transgenes to both mitotic and postmitotic cells in a state which can be maintained for extended periods. The invention pertains to the use of this vector system in introducing and expressing gene sequences in mitotic and postmitotic cells for therapeutic purposes.

IPC 1-7

C12N 15/63; A01N 43/04; A61K 31/70

IPC 8 full level

C12N 15/09 (2006.01); A61K 31/54 (2006.01); A61K 31/711 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 38/44 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 21/04 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 35/00 (2006.01); C07K 14/015 (2006.01); C12N 15/869 (2006.01); C12P 21/02 (2006.01)

CPC (source: EP)

A61P 21/04 (2017.12); A61P 25/16 (2017.12); A61P 25/28 (2017.12); A61P 35/00 (2017.12); C07K 14/005 (2013.01); C12N 15/86 (2013.01); A61K 48/00 (2013.01); C12N 2710/16643 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01)

Citation (search report)

• [T] ROBBINS P D ET AL: "VIRAL VECTORS FOR GENE THERAPY", PHARMACOLOGY AND THERAPEUTICS, ELSEVIER, GB, vol. 80, no. 1, 1998, pages 35 - 47, XP002927113, ISSN: 0163-7258
• [AD] PECHAN P A ET AL: "A novel 'piggyback' packaging system for herpes simplex virus amplicon vectors.", HUMAN GENE THERAPY. UNITED STATES 20 OCT 1996, vol. 7, no. 16, 20 October 1996 (1996-10-20), pages 2003 - 2013, XP001107052, ISSN: 1043-0342
• See references of WO 9821345A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9821345 A1 19980522; AU 5199998 A 19980603; AU 734063 B2 20010531; CA 2271777 A1 19980522; EP 0946733 A1 19991006; EP 0946733 A4 20030108; JP 2002503086 A 20020129

DOCDB simple family (application)

US 9720422 W 19971112; AU 5199998 A 19971112; CA 2271777 A 19971112; EP 97946914 A 19971112; JP 52271098 A 19971112