EP 0947505 B1 20020717 - Process for preparing optically active 4-hydroxy-2-pyrrolidone
Title (en)
Process for preparing optically active 4-hydroxy-2-pyrrolidone
Title (de)
Verfahren zur Herstellung optisch aktiver 4-Hydroxy-2-pyrrolidone
Title (fr)
Procédé de préparation de dérivés optiquement actifs de 4-hydroxy-2-pyrrolidone
Publication
Application
Priority
JP 10187398 A 19980331
Abstract (en)
[origin: EP0947505A2] Disclosed is a novel process for preparing an optically active 4-hydroxy-2-pyrrolidone which is useful as starting material in pharmaceutical applications. The process for preparing an optically active 4-hydroxy-2-pyrrolidone comprises steps of asymmetrically hydrogenating a salt of 4-amino-3-oxobutanoic acid and/or a salt of a 4-amino-3-oxobutanoic acid ester in the presence of a ruthenium-optically active phosphine complex as catalyst and a lower alkanol as solvent, to produce a salt of a lower alkyl ester of an optically active 4-amino-3-hydroxybutanoic acid, followed by a cyclization reaction in the presence of a base.
IPC 1-7
IPC 8 full level
B01J 31/24 (2006.01); C07D 207/273 (2006.01); C07D 207/26 (2006.01)
CPC (source: EP)
C07D 207/273 (2013.01)
Designated contracting state (EPC)
CH DE FR GB IT LI
DOCDB simple family (publication)
EP 0947505 A2 19991006; EP 0947505 A3 20000920; EP 0947505 B1 20020717; DE 69902118 D1 20020822; DE 69902118 T2 20030327; JP 4187822 B2 20081126; JP H11286479 A 19991019
DOCDB simple family (application)
EP 99400778 A 19990330; DE 69902118 T 19990330; JP 10187398 A 19980331