EP 0948493 A1 19991013 - INDENE INHIBITORS OF COX-2
Title (en)
INDENE INHIBITORS OF COX-2
Title (de)
INDENE ALS INHIBITOREN VON COX-2
Title (fr)
INDENES INHIBITEURS DU COX-2
Publication
Application
Priority
- US 9720231 W 19971110
- US 74794896 A 19961112
Abstract (en)
[origin: WO9821195A1] This invention provides compounds of formula (I) having structure (1) wherein: R<1> is hydrogen, halogen, alkyl, alkoxy, fluoroalkoxy, trifluoromethyl, alkylthio, or SCF3; R<2> and R<3> are each independently hydrogen or alkyl, or R<2> and R<3> may be taken together to form a saturated cycloalkyl ring; and R<4>, R<5>, R<6>, R<7> and R<8> are each independently hydrogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, halogen, fluoroalkoxy, CF3 or SCF3 which are useful in the treatment of arthritic disorders, colorectal cancer, and Alzheimer's disease.
IPC 1-7
IPC 8 full level
A61K 31/365 (2006.01); A61P 19/02 (2006.01); A61P 25/28 (2006.01); A61P 35/00 (2006.01); C07D 307/60 (2006.01)
CPC (source: EP KR)
A61P 19/02 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07D 307/60 (2013.01 - EP KR)
Citation (search report)
See references of WO 9821195A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9821195 A1 19980522; AU 5105598 A 19980603; BR 9713346 A 20000509; CA 2269035 A1 19980522; CN 1237162 A 19991201; EP 0948493 A1 19991013; HU P9904696 A2 20000528; JP 2001504118 A 20010327; KR 20000053227 A 20000825
DOCDB simple family (application)
US 9720231 W 19971110; AU 5105598 A 19971110; BR 9713346 A 19971110; CA 2269035 A 19971110; CN 97199655 A 19971110; EP 97945622 A 19971110; HU P9904696 A 19971110; JP 52266398 A 19971110; KR 19997004202 A 19990512