EP 0948494 A1 19991013 - SUBSTITUTED BENZO 1,4 DIOXANES AS ANTIOBESITY AGENTS
Title (en)
SUBSTITUTED BENZO 1,4 DIOXANES AS ANTIOBESITY AGENTS
Title (de)
SUBSTITUIERTE BENZO¬1,4 DIOXANE ALS MITTEL GEGEN FETLEIBIGKEIT
Title (fr)
BENZO 1,4 DIOXANNES SUBSTITUES UTILISES COMME AGENTS ANTI-OBESITE
Publication
Application
Priority
- US 9724019 W 19971218
- US 77474996 A 19961230
Abstract (en)
[origin: WO9829405A1] This invention relates to novel substituted 1,4-benzodioxane compounds having antidiabetic, antihyperglycemic, and antiobesity properties represented by formula (II) wherein R<1> and R<6> are independently hydrogen, C1 to C6 alkyl, trifluoromethyl, cyano, C1 to C6 alkoxy, or halogen; R<2> is hydrogen or C1 to C6 trialkylsilyl; R<3> is hydrogen or C1 to C6 alkoxycarbonyl; or R<2> and R<3> are joined to form the oxazolidinone ring (III); R<4> and R<5> are independently hydrogen or C1 to C6 alkyl; R<7> and R<8> are independently OR<9> or NR<10>R<11>; R<9> is hydrogen, C1 to C12 alkyl, C1 to C12 cycloalkyl, C1 to C12 silylalkyl, phenyl, naphthyl, phenyl C<1> to C<6> alkyl, C1 to C6 alkoxy C1 to C6 alkyl, pyridyl, thiophenyl, furanyl, imidazolyl, oxazolyl, -CHR<12>COOR<13>, -CHR<12>C(O)R<13>, -CHR<12>CONR<10>R<11>, -CHR<12>OCOOR<13>, or -CHR<12>OC(O)R<13>; R<10> and R<11> are independently hydrogen, C1 to C12 alkyl, phenyl, naphthyl, phenyl-C1 to C6 alkyl, furanylalkyl, or alkoxycarbonylalkyl; R<12> and R<13> are independently hydrogen, C1 to C12 alkyl, phenyl, naphthyl, or phenyl-C1 to C6 alkyl; and the pharmaceutically acceptable salts thereof, a salt thereof; an enantiomer thereof, the racemic mixtures thereof, and the diastereomeric mixtures thereof.
IPC 1-7
IPC 8 full level
A61K 31/357 (2006.01); A61K 31/422 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); C07D 319/20 (2006.01); C07D 413/06 (2006.01)
CPC (source: EP KR)
A61P 3/04 (2017.12 - EP); A61P 3/10 (2017.12 - EP); C07D 319/20 (2013.01 - EP KR); C07D 413/06 (2013.01 - EP)
Citation (search report)
See references of WO 9829405A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
Designated extension state (EPC)
AL LT LV RO SI
DOCDB simple family (publication)
WO 9829405 A1 19980709; AU 5723098 A 19980731; BR 9714109 A 20000321; CA 2271885 A1 19980709; EP 0948494 A1 19991013; HU P0000768 A2 20010528; IL 129715 A0 20000229; JP 2001507704 A 20010612; KR 20000062404 A 20001025; NZ 336235 A 20001124
DOCDB simple family (application)
US 9724019 W 19971218; AU 5723098 A 19971218; BR 9714109 A 19971218; CA 2271885 A 19971218; EP 97953494 A 19971218; HU P0000768 A 19971218; IL 12971597 A 19971218; JP 53026098 A 19971218; KR 19997005997 A 19990630; NZ 33623597 A 19971218