EP 0950060 A4 20000705 - ANTISENSE INHIBITION OF HUMAN ADHESION MOLECULES
Title (en)
ANTISENSE INHIBITION OF HUMAN ADHESION MOLECULES
Title (de)
GEGENSTRANG-HEMMUNG VON MENSCHLICHEN ADHÄSIONSMOLEKÜLEN
Title (fr)
INHIBITION ANTISENS DE MOLECULES D'ADHESION HUMAINES
Publication
Application
Priority
US 9619194 W 19961202
Abstract (en)
[origin: WO9824797A1] The present invention provides a method for the treatment of human conditions and diseases that have an inflammatory component, including but not limited to acne, psoriasis, arthritis, transplanted organ rejection, wounds, burns, septic shock and inflammatory complications of shock. A process for selectively inhibiting the expression of the human ICAM-I, human E-selectin, or human VCAM-1 mRNA transcripts using at least one oligonucleotide which is complementary to at least a portion of the human ICAM-I, human E-selectin, or human VCAM-1 mRNAs is disclosed, as are oligonucleotides which are complementary to portions of the ICAM-I, human E-selectin, or human VCAM-1 mRNAs and compositions comprising the aforementioned oligonucleotides.
IPC 1-7
IPC 8 full level
A61K 31/7088 (2006.01); A61K 48/00 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C12N 15/09 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 29/00 (2017.12); A61P 43/00 (2017.12); C12N 15/1138 (2013.01); A61K 38/00 (2013.01); C12N 2310/315 (2013.01)
Citation (search report)
- [X] WO 9615780 A1 19960530 - ISIS PHARMACEUTICALS INC [US], et al
- [X] WO 9422488 A1 19941013 - ISIS PHARMACEUTICALS INC [US]
- [A] WO 9301286 A2 19930121 - MASSACHUSETTS INST TECHNOLOGY [US]
- [E] US 5580969 A 19961203 - HOKE GLENN D [US], et al
- [DX] LEE CH. ET AL.: "Antisense gene suppression against human ICAM-1, ELAM-1, and VCAM-1 in cultured human umbilical vein endothelial cells.", SHOCK 1995 JUL;4(1):1-10, XP000892942
- [X] BENNETT C F ET AL: "INHIBITION OF ICAM-1, VCAM-1 AND E-SELECTIN EXPRESSION WITH ANTISENSE OLIGONUCLEOTIDES", JOURNAL OF CELLULAR BIOCHEMISTRY. SUPPLEMENT, 9 January 1993 (1993-01-09), pages 354, XP000647853
- See references of WO 9824797A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9824797 A1 19980611; AU 1564897 A 19980629; CA 2273203 A1 19980611; EP 0950060 A1 19991020; EP 0950060 A4 20000705; JP 2001505432 A 20010424
DOCDB simple family (application)
US 9619194 W 19961202; AU 1564897 A 19961202; CA 2273203 A 19961202; EP 96945380 A 19961202; JP 52553398 A 19961202