EP 0952770 A4 19991222 - SYSTEM FOR RENDERING SUBSTANTIALLY NON-DISSOLUBLE BIO-AFFECTING AGENTS BIO-AVAILABLE

Title (en)

SYSTEM FOR RENDERING SUBSTANTIALLY NON-DISSOLUBLE BIO-AFFECTING AGENTS BIO-AVAILABLE

Title (de)

VERFAHREN UM GRUNDSATZLICHE UNLOSLICHE BIOLOGISCHE WIRKSAME STOFFE BIOLOGSICH VERFUGBAR ZU MACHEN

Title (fr)

SYSTEME PERMETTANT DE RENDRE BIODISPONIBLES DES AGENTS BIOALTERANTS SENSIBLEMENT NON SOLUBLES

Publication

EP 0952770 A4 19991222 (EN)

Application

EP 96932188 A 19960909

Priority

US 9614457 W 19960909
US 52453195 A 19950907

Abstract (en)

[origin: WO9708950A1] The present invention is a method of preparing a system for delivering a bio-affecting agent and the composition prepared thereby. The invention includes forming a solid dispersion of the bio-affecting agent in an increased energy state in a water-soluble polymer which is compatible with the bio-affecting agent. As a consequence of transforming the bio-affecting agent to an increased-energy condition and freezing it in such condition in a water-soluble polymer, the bio-affecting agent is made available ("bio-available") to a bio-system upon dissolution of the polymer. This method and composition has been found extremely effective for delivery of otherwise substantially non-soluble drugs and other bio-affecting ingredients.

IPC 1-7

A01N 25/28; A61K 9/26; A61K 9/50; B01J 13/04

IPC 8 full level

A01N 25/10 (2006.01); A01N 25/14 (2006.01); A61K 9/14 (2006.01); A61K 9/20 (2006.01); A61K 9/26 (2006.01); A61K 9/48 (2006.01); A61K 9/70 (2006.01); A61K 47/32 (2006.01); B01J 13/04 (2006.01)

CPC (source: EP)

A01N 25/10 (2013.01); A61K 9/146 (2013.01); A61K 9/70 (2013.01); B01J 13/04 (2013.01)

Citation (search report)

[XY] EP 0240904 A2 19871014 - BASF AG [DE]
[Y] WO 9324154 A1 19931209 - FUISZ TECHNOLOGIES LTD [US], et al
[A] WO 9311750 A1 19930624 - FUISZ TECHNOLOGIES LTD [US]
[A] WO 9313773 A1 19930722 - ETHICAL PHARMA LTD [GB]
[XY] PATENT ABSTRACTS OF JAPAN vol. 1997, no. 03 31 March 1997 (1997-03-31)
See references of WO 9708950A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9708950 A1 19970313; AU 7106996 A 19970327; CA 2231050 A1 19970313; EP 0952770 A1 19991103; EP 0952770 A4 19991222; JP H11514979 A 19991221

DOCDB simple family (application)

US 9614457 W 19960909; AU 7106996 A 19960909; CA 2231050 A 19960909; EP 96932188 A 19960909; JP 51144497 A 19960909