Global Patent Index - EP 0952841 A4

EP 0952841 A4 2000-11-02 - SITE-SPECIFIC BIOMOLECULAR COMPLEXES

Title (en)

SITE-SPECIFIC BIOMOLECULAR COMPLEXES

Title (de)

BIOMOLEKULARE KOMPLEXE FÜR GERICHTETEN TRANSPORT VON ARZNEIMITTELN IN SPEZIELLE REGIONEN

Title (fr)

COMPLEXES BIOMOLECULAIRES DIRIGES

Publication

EP 0952841 A4 (EN)

Application

EP 95929378 A

Priority

  • US 9509870 W
  • US 28632794 A
  • US 48769395 A

Abstract (en)

[origin: WO9604001A1] The present invention describes site-specific biomolecular complexes comprising a therapeutic, prophylactic and diagnostic agent, called also biologically active molecule and an omega-3 fatty acid and derivatives thereof. The complexes are further covalently bonded with cationic carriers and permeabilizer peptides for delivery across the blood-brain barrier and with targeting moieties for uptake by target brain cells. Said complexes are particularly useful for delivery of a biologically active agent to the glial tissue of the brain as well as to the cortical, cholinergic and adrenergic neurons. The preferred therapeutic complexes or conjugates comprise an omega-3 fatty acid such as alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid and derivatives thereof.

IPC 1-7 (main, further and additional classification)

A61K 38/00; A61K 38/18; A61K 31/70; A61K 39/44; A61K 39/385; A61K 39/395; A61K 38/46

IPC 8 full level (invention and additional information)

A61K 47/48 (2006.01)

CPC (invention and additional information)

A61K 47/645 (2017.08); A61K 47/542 (2017.08); A61K 47/6415 (2017.08)

Citation (search report)

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9604001 A1 19960215; AU 3275595 A 19960304; EP 0952841 A1 19991103; EP 0952841 A4 20001102

INPADOC legal status


2008-02-20 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20070301

2000-11-02 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20000914

2000-11-02 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

2000-11-02 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7A 61K 38/00 A, 7A 61K 38/18 B, 7A 61K 31/70 B, 7A 61K 39/44 B, 7A 61K 39/385 B, 7A 61K 39/395 B, 7A 61K 38/46 B

1999-11-03 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19971118

1999-11-03 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE