EP 0953046 B1 20090701 - HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELL ANTIGEN AND METHODS FOR ITS USE
Title (en)
HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELL ANTIGEN AND METHODS FOR ITS USE
Title (de)
MENSCHLICHE HÄMATOPOIETISCHE STAMM UND VORLÄUFERZELLANTIGEN UND METHODEN ZU DESSEN VERWENDUNG
Title (fr)
ANTIGENE DE CELLULES HEMATOPOIETIQUES HUMAINES SOUCHES ET PARENTES ET LEURS PROCEDES D'UTILISATION
Publication
Application
Priority
- US 9706930 W 19970425
- US 63989196 A 19960426
- US 84238297 A 19970423
Abstract (en)
[origin: WO9741224A1] A hematopoietic progenitor cell antigen and reagents, notably antibodies, that specifically bind to the antigen are provided. Expression of the antigen is highly tissue specific. It is only detected on a subset of hematopoietic progenitor cells derived from human bone marrow, fetal bone marrow and liver, cord blood and adult peripheral blood. The subset of cells recognized by AC133 is CD34<bright> and contains substantially all of the CFU-GM activity present in the CD34<+> population. This highly specific distribution of AC133 makes it exceptionally useful as a reagent for isolating and characterizing human hematopoietic progenitor and stem cells. Cells selected for expression of AC133 antigen can be further purified by selection for other hematopoietic stem cell and progenitor cell markers.
IPC 8 full level
C12N 15/02 (2006.01); C12N 15/12 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C07K 16/40 (2006.01); C12N 5/06 (2006.01); C12N 5/08 (2006.01); C12N 5/10 (2006.01); C12N 5/20 (2006.01); C12P 21/08 (2006.01); G01N 33/53 (2006.01); G01N 33/569 (2006.01); G01N 33/577 (2006.01)
CPC (source: EP US)
A61P 7/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); C07K 14/705 (2013.01 - EP US); C07K 16/28 (2013.01 - EP US); G01N 33/56966 (2013.01 - EP US); Y10S 530/806 (2013.01 - EP US); Y10S 530/838 (2013.01 - EP US)
Citation (examination)
- WO 8706954 A1 19871119 - GENETICS INST [US]
- EP 0387646 A1 19900919 - WAKO PURE CHEM IND LTD [JP]
- JP H02222686 A 19900905 - NAT FOOD RES
- US 5643779 A 19970701 - EHRLICH STANISLAV [FR], et al
- DATABASE NCBI [online] 8 May 1996 (1996-05-08)
- WESS LUDGER: "Building on safe ground", BIOCENTURY, vol. 12, no. 42, 27 September 2004 (2004-09-27), pages A1 - A7
- MEDVINSKY A.L. ET AL: "An early pre-liver intra-embryonic source of CFU-S in the developing mouse", NATURE, vol. 364, 1 July 1993 (1993-07-01), pages 64 - 67
- MIRAGLIA S. ET AL: "A response to AC133 hematopoietic cell antigen: human homologue of mouse kidney Prominin or distinct member of a novel protein family?", BLOOD, vol. 91, no. 11, 1 June 1998 (1998-06-01), pages 4390 - 4391, XP002143048
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9741224 A1 19971106; AT E435282 T1 20090715; AU 2682197 A 19971119; AU 720938 B2 20000615; CA 2251604 A1 19971106; CA 2251604 C 20120529; DE 69739480 D1 20090813; DK 0953046 T3 20090810; EP 0953046 A1 19991103; EP 0953046 B1 20090701; ES 2327691 T3 20091102; JP 2000509277 A 20000725; JP 2006149396 A 20060615; JP 2006246898 A 20060921; JP 3908279 B2 20070425; US 2001051372 A1 20011213; US 2005214861 A1 20050929; US 2009093052 A1 20090409; US 6455678 B1 20020924; US 8084033 B2 20111227
DOCDB simple family (application)
US 9706930 W 19970425; AT 97918811 T 19970425; AU 2682197 A 19970425; CA 2251604 A 19970425; DE 69739480 T 19970425; DK 97918811 T 19970425; EP 97918811 A 19970425; ES 97918811 T 19970425; JP 2006004071 A 20060111; JP 2006153522 A 20060601; JP 53904597 A 19970425; US 16933608 A 20080708; US 82790704 A 20040419; US 84238297 A 19970423; US 88185301 A 20010613