EP 0953053 A2 19991103 - VIRAL PARTICLES WHICH ARE MASKED OR UNMASKED WITH RESPECT TO A CELL RECEPTOR
Title (en)
VIRAL PARTICLES WHICH ARE MASKED OR UNMASKED WITH RESPECT TO A CELL RECEPTOR
Title (de)
GEGENÜBER DEM ZELLREZEPTOR MASKIERTE ODER NICHT-MASKIERTE VIRENPARTIKELN
Title (fr)
PARTICULES VIRALES MASQUEES OU DEMASQUEES VIS-A-VIS DU RECEPTEUR CELLULAIRE
Publication
Application
Priority
- FR 9700870 W 19970516
- FR 9606234 A 19960520
Abstract (en)
[origin: WO9744474A2] The invention features the use of a peptide for transferring genes in a eukaryotic target cell, which peptide has about 10 to about 200, in particular about 15 to about 150 amino acids, and advantageously about 20 amino acids, in which 30 % at least of the amino acids are constituted by proline radicals, which proline radicals are regularly arranged so as to induce polypeptide chain turnings at about 180 DEG (" beta -turn" or "reverse-turn"), these turns being regularly spaced and gathering in a polyproline beta -turn helix, in a polypeptide construction containing, on the said peptide N-terminal side (upstream), an N-terminal (upstream) proteinic domain capable of recognising a targeted surface molecule or an antigen expressed on a cellular surface, in particular an appropriate receptor (targeted receptor) located on the said eukaryotic cell, and on the said peptide C-terminal side (downstream), a C-terminal (downstream) protein domain capable of recognising an appropriate receptor (auxiliary receptor) located on the said eukaryotic cell, which peptide is capable of facilitating or inhibiting interaction between the C-terminal (downstream) protein domain and the auxiliary receptor, the inhibition of this interaction taking place so long as the N-terminal (upstream) protein domain has not interacted with the targeted receptor, and the facilitating of the interaction between the C-terminal (downstream) protein domain and the auxiliary receptor taking place when the N-terminal (upstream) protein domain has interacted with the targeted receptor.
IPC 1-7
C12N 15/86; C12N 7/04; C12N 15/87; C07K 14/15; C07K 1/107; C12N 15/62
IPC 8 full level
A61K 31/70 (2006.01); A61K 31/7088 (2006.01); A61K 31/711 (2006.01); A61K 47/42 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); C07K 1/107 (2006.01); C07K 14/15 (2006.01); C07K 14/485 (2006.01); C12N 7/00 (2006.01); C12N 7/04 (2006.01); C12N 15/09 (2006.01); C12N 15/62 (2006.01); C12N 15/867 (2006.01); C12N 15/87 (2006.01)
CPC (source: EP)
A61K 47/6901 (2017.07); C07K 1/1075 (2013.01); C07K 14/005 (2013.01); C07K 14/485 (2013.01); C12N 7/00 (2013.01); C12N 15/62 (2013.01); C12N 15/86 (2013.01); C12N 15/87 (2013.01); A61K 48/00 (2013.01); C07K 2319/00 (2013.01); C12N 2740/13022 (2013.01); C12N 2740/13043 (2013.01); C12N 2740/13045 (2013.01); C12N 2740/13062 (2013.01); C12N 2810/60 (2013.01); C12N 2810/6018 (2013.01); C12N 2810/6054 (2013.01); C12N 2810/80 (2013.01); C12N 2810/851 (2013.01); C12N 2810/852 (2013.01); C12N 2810/854 (2013.01)
Citation (search report)
See references of WO 9744474A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9744474 A2 19971127; WO 9744474 A3 19980305; AU 3035697 A 19971209; AU 725632 B2 20001019; CA 2253874 A1 19971127; EP 0953053 A2 19991103; FR 2748747 A1 19971121; FR 2748747 B1 19980807; JP 2000511051 A 20000829
DOCDB simple family (application)
FR 9700870 W 19970516; AU 3035697 A 19970516; CA 2253874 A 19970516; EP 97925095 A 19970516; FR 9606234 A 19960520; JP 54170597 A 19970516