Global Patent Index - EP 0956032 A4

EP 0956032 A4 2002-09-04 - PROTEINS AND COMPOSITIONS FOR MODULATING MITOSIS

Title (en)

PROTEINS AND COMPOSITIONS FOR MODULATING MITOSIS

Title (de)

PROTEINE UND ZUSAMMENSETZUNGEN ZUM MODULIEREN VON MITOSIS

Title (fr)

PROTEINES ET COMPOSITIONS PERMETTANT DE MODULER LA MITOSE

Publication

EP 0956032 A4 (EN)

Application

EP 97950984 A

Priority

  • US 9723385 W
  • US 3360096 P

Abstract (en)

[origin: WO9827994A1] The protein encoded by the human gene HEC(<u>h</u>ighly <u>e</u>xpressed in <u>c</u>ancer) contains a long series of leucine heptad repeats and appears to be crucial for normal mitosis. HEC localizes to the nuclei of interphase cells and redistributes to centromeres during M phase. Ectopic expression of a mutant HEC containing only the heptad repeats results in the inability of cells to divide more than once. Inactivation of HEC results in disordered sister chromatid alignment and separation, as well as in the formation of non viable cells with multiple, fragmented micronuclei. HEC interacts through its leucine heptad repeats with several proteins involved in mitosis, including nek2, sb1.8, and two different regulatory subunits of the 26S proteasome, MSS1 and p45. These biochemical properties of HEC suggest its potential roles in modulating proteins important for spindle attachment to kinetochores, sister chromatic movement, and M phase progression.

IPC 1-7 (main, further and additional classification)

A61K 38/08; A61K 38/17; C07H 21/04; C07K 7/00; C07K 14/435; C12N 5/10; C12N 15/12; C12N 15/70; C12N 15/74; C12N 15/79; C12N 15/85; C12P 21/02

IPC 8 full level (invention and additional information)

G01N 33/53 (2006.01); A61K 38/16 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/435 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12Q 1/68 (2006.01)

CPC (invention and additional information)

C07K 14/4702 (2013.01)

Citation (search report)

  • [E] EP 1022286 A1 20000726 - ONO PHARMACEUTICAL CO [JP] & WO 9918126 A1 19990415 - ONO PHARMACEUTICAL CO [JP], et al
  • [X] DATABASE GENBANK [online] 20 March 1995 (1995-03-20), HILLIER ET AL.: "The WashU-Merck EST project", XP002203305, Database accession no. T89463
  • [X] DATABASE GENBANK [online] 25 August 1995 (1995-08-25), HILLIER ET AL.: "The WashU-Merck EST project", XP002203306, Database accession no. R92253
  • [A] COMPTON D A ET AL: "PRIMARY STRUCTURE OF NUMA, AN INTRANUCLEAR PROTEIN THAT DEFINES A NOVEL PATHWAY FOR SEGREGATION OF PROTEINS AT MITOSIS", JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIVERSITY PRESS, NEW YORK, US, US, vol. 116, no. 6, 1 March 1992 (1992-03-01), pages 1395 - 1408, XP000601680, ISSN: 0021-9525
  • [A] DURFEE T ET AL: "THE RETINOBLASTOMA PROTEIN ASSOCIATES WITH THE PROTEIN PHOSPHATASE TYPE 1 CATALYTIC SUBUNIT", GENES AND DEVELOPMENT, COLD SPRING HARBOR, NY, US, vol. 7, no. 4, 1 April 1993 (1993-04-01), pages 555 - 567, XP000571493, ISSN: 0890-9369
  • See also references of WO 9827994A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9827994 A1 19980702; AU 5384898 A 19980717; CA 2274734 A1 19980702; EP 0956032 A1 19991117; EP 0956032 A4 20020904; JP 2001507226 A 20010605

INPADOC legal status


2003-06-04 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20020701

2002-09-04 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20020718

2002-09-04 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

1999-11-17 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990716

1999-11-17 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE