EP 0958364 A1 19991124 - Enhancement of DNA immunization by co-expression of IL-12 subunits
Title (en)
Enhancement of DNA immunization by co-expression of IL-12 subunits
Title (de)
Verstärkung der DNA Immunisierung durch Coexpression der Untereinheiten von IL-12
Title (fr)
Amplification de l'immunisation à l'ADN par la coexpression des sous-unités de l'IL-12
Publication
Application
Priority
- US 9719502 W 19971023
- US 2861396 P 19961023
Abstract (en)
[origin: WO9817799A1] Improved vaccines which include a nucleotide sequence that encodes IL-12, GM-CSF, IL-1, TNF- alpha , TNF- beta , IL-2, IL-4, IL-5, IL-10, IL-15, IL-18, and/or BL-1 operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Pharmaceutical compositions comprising nucleic acid molecules that encode one or more immunomodulatory proteins selected from the group consisting of IL-12, GM-CSF, IL-1, TNF- alpha , TNF- beta , IL-2, IL-4, IL-5, IL-10, IL-15, IL-18, and BL-1 are disclosed. An immunomodulatory protein, BL-1, and nucleic acid molecules that encode BL-1 are disclosed. Methods of making and using BL-1 are disclosed.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); C12N 15/19 (2006.01); A61K 9/00 (2006.01); A61K 31/00 (2006.01); A61K 31/711 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61K 39/21 (2006.01); A61K 39/39 (2006.01); A61K 48/00 (2006.01); A61P 31/04 (2006.01); A61P 31/18 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C07K 14/54 (2006.01); C07K 16/24 (2006.01); C12N 7/00 (2006.01); C12N 15/18 (2006.01)
CPC (source: EP KR US)
A61K 9/0019 (2013.01 - EP); A61K 39/12 (2013.01 - EP); A61K 39/21 (2013.01 - EP); A61K 39/39 (2013.01 - EP); A61K 48/00 (2013.01 - EP); A61P 31/00 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61P 31/18 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 37/02 (2018.01 - EP); A61P 37/04 (2018.01 - EP); A61P 37/06 (2018.01 - EP); C07K 14/54 (2013.01 - EP); C12N 15/11 (2013.01 - KR); A01K 2217/05 (2013.01 - EP); A61K 38/00 (2013.01 - EP); A61K 39/00 (2013.01 - EP KR US); A61K 2039/53 (2013.01 - EP); A61K 2039/55522 (2013.01 - EP); A61K 2039/55527 (2013.01 - EP); A61K 2039/55533 (2013.01 - EP); A61K 2039/55538 (2013.01 - EP); A61K 2039/57 (2013.01 - EP); C12N 2740/16134 (2013.01 - EP); C12N 2740/16234 (2013.01 - EP); C12N 2740/16334 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9817799 A1 19980430; AU 5002297 A 19980515; AU 729579 B2 20010201; BR 9712852 A 19991116; CA 2269074 A1 19980430; CA 2745736 A1 19980430; CA 2745736 C 20161122; CA 2751712 A1 19980430; CA 2751712 C 20161122; CN 1242045 A 20000119; CN 1257976 C 20060531; CN 1868545 A 20061129; EP 0958364 A1 19991124; EP 0958364 A4 20011031; JP 2001507216 A 20010605; JP 2008194046 A 20080828; JP 2009232860 A 20091015; KR 100629835 B1 20060929; KR 100780158 B1 20071127; KR 20000052710 A 20000825; KR 20050008860 A 20050121; KR 20050053796 A 20050608; KR 20070108418 A 20071109
DOCDB simple family (application)
US 9719502 W 19971023; AU 5002297 A 19971023; BR 9712852 A 19971023; CA 2269074 A 19971023; CA 2745736 A 19971023; CA 2751712 A 19971023; CN 200610071869 A 19971023; CN 97180897 A 19971023; EP 97912961 A 19971023; JP 2008045969 A 20080227; JP 2009164572 A 20090713; JP 51971498 A 19971023; KR 19997003507 A 19990422; KR 20047021499 A 19971023; KR 20057008602 A 20050513; KR 20077024846 A 20071026