Global Patent Index - EP 0959877 A4

EP 0959877 A4 20000823 - CORRECTION OF GENETIC DEFECTS USING CHEMICAL CHAPERONES

Title (en)

CORRECTION OF GENETIC DEFECTS USING CHEMICAL CHAPERONES

Title (de)

KORREKTUR DER GENETISCHEN FEHLER MITTELS CHEMISCHE BEGLEITER

Title (fr)

CORRECTION DES DEFAILLANCES GENETIQUES A L'AIDE DE CHAPERONS CHIMIQUES

Publication

EP 0959877 A4 20000823 (EN)

Application

EP 97920243 A 19970409

Priority

  • US 9705846 W 19970409
  • US 1515596 P 19960410

Abstract (en)

[origin: WO9737645A1] A method for stabilizing intracellular proteins known to cause disease, said method comprising contacting a cell with stabilizing agents such as DMSO, sugars, amino acids and TMAO, wherein the proteins are stabilized and the disease state lessened.

IPC 1-7

A61K 31/135; A61K 31/13; A61K 31/10; A61K 31/045

IPC 8 full level

C12N 15/09 (2006.01); A61K 31/00 (2006.01); A61K 31/045 (2006.01); A61K 31/047 (2006.01); A61K 31/10 (2006.01); A61K 31/13 (2006.01); A61K 31/131 (2006.01); A61K 31/185 (2006.01); A61K 31/195 (2006.01); A61K 31/197 (2006.01); A61K 31/198 (2006.01); A61K 31/205 (2006.01); A61K 31/401 (2006.01); A61K 31/77 (2006.01); A61K 33/00 (2006.01); A61K 45/00 (2006.01); A61P 43/00 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12Q 1/00 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)

CPC (source: EP US)

A61K 31/047 (2013.01 - EP US); A61K 31/10 (2013.01 - EP US); A61K 31/131 (2013.01 - EP US); A61K 31/185 (2013.01 - EP US); A61K 31/197 (2013.01 - EP US); A61K 31/198 (2013.01 - EP US); A61K 31/205 (2013.01 - EP US); A61K 31/401 (2013.01 - EP US); A61K 31/77 (2013.01 - EP US); A61P 43/00 (2017.12 - EP); G01N 33/5008 (2013.01 - EP US); G01N 33/502 (2013.01 - EP US); G01N 33/5044 (2013.01 - EP US); G01N 33/5091 (2013.01 - EP US); G01N 2800/382 (2013.01 - EP US); Y10S 436/811 (2013.01 - EP US)

Citation (search report)

  • [XP] EP 0764442 A1 19970326 - HOLT JOHN ALFRED GORTON [AU]
  • [X] SATO ET AL: "glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation", J. BIOL. CHEM., vol. 271, no. 2, 12 January 1996 (1996-01-12), pages 635 - 638, XP000910275
  • [XP] BROWN ET AL: "chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein", CELL STRESS AND CHAPERONES, vol. 1, no. 2, June 1996 (1996-06-01), pages 117 - 125, XP002093438
  • [XP] TATZELT ET AL: "chemical chaperones interfere with the formation of scrapie prion protein", EMBO JOURNAL, vol. 15, no. 23, 2 December 1996 (1996-12-02), pages 6363 - 6373, XP000910294
  • See references of WO 9737645A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9737645 A1 19971016; AU 2448597 A 19971029; AU 734905 B2 20010628; CA 2250780 A1 19971016; EP 0959877 A1 19991201; EP 0959877 A4 20000823; JP 2000509971 A 20000808; US 5900360 A 19990504

DOCDB simple family (application)

US 9705846 W 19970409; AU 2448597 A 19970409; CA 2250780 A 19970409; EP 97920243 A 19970409; JP 53645397 A 19970409; US 83869197 A 19970409