EP 0959886 A4 20010502 - TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS

Title (en)

TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS

Title (de)

TRIARYL SUBSTITUIERTE IMIDAZOLE ALS GLUCAGON ANTAGONISTEN

Title (fr)

IMIDAZOLES A SUBSTITUTION TRIARYLE EN TANT QU'ANTAGONISTES DU GLUCAGON

Publication

EP 0959886 A4 20010502 (EN)

Application

EP 97948343 A 19971117

Priority

GB 9700540 A 19970113
US 9721020 W 19971117
US 3146696 P 19961120

Abstract (en)

[origin: WO9822109A1] 2,4-Diaryl-5-pyridylimidazoles are glucagon antagonists. The compounds block the action of glucagon at its receptor. Thus, the compounds can be used in the prophylaxis or treatment of disease states in mammals mediated by elevated levels of glucagon. Examples of such disease states include diabetes, obesity, hypertension, and cachexia and the like.

IPC 1-7

A61K 31/44; C07D 401/04

IPC 8 full level

A61K 31/4439 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 9/12 (2006.01); A61P 39/00 (2006.01); A61P 43/00 (2006.01); C07D 401/04 (2006.01)

CPC (source: EP)

A61P 3/04 (2017.12); A61P 3/10 (2017.12); A61P 9/12 (2017.12); A61P 39/00 (2017.12); A61P 43/00 (2017.12); C07D 401/04 (2013.01)

Citation (search report)

[X] WO 9314081 A1 19930722 - SMITHKLINE BEECHAM CORP [US]
[X] WO 9618626 A1 19960620 - HOFFMANN LA ROCHE [CH], et al
[X] WO 9503297 A1 19950202 - SMITHKLINE BEECHAM CORP [US], et al
[X] US 3929807 A 19751230 - FITZI KONRAD
[Y] US 3707475 A 19721226 - LOMBARDINO JOSEPH GEORGE
[Y] WO 9621654 A1 19960718 - SMITHKLINE BEECHAM CORP [US], et al
[X] GALLAGHER T F ET AL: "2,4,5- Triarylimidazole inhibitors of IL-1 biosynthesis", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 5, no. 11, 8 June 1995 (1995-06-08), pages 1171 - 1176, XP004135499, ISSN: 0960-894X
See references of WO 9822109A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9822109 A1 19980528; AU 5442898 A 19980610; AU 730295 B2 20010301; CA 2271893 A1 19980528; EP 0959886 A1 19991201; EP 0959886 A4 20010502; JP 2000514088 A 20001024

DOCDB simple family (application)

US 9721020 W 19971117; AU 5442898 A 19971117; CA 2271893 A 19971117; EP 97948343 A 19971117; JP 52379898 A 19971117