EP 0960110 B8 20021127 - 3-ARYL SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDINE DERIVATIVES; CORTICOTROPIN-RELEASING FACTOR RECEPTOR (CRF1) SPECIFIC LIGANDS
Title (en)
3-ARYL SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDINE DERIVATIVES; CORTICOTROPIN-RELEASING FACTOR RECEPTOR (CRF1) SPECIFIC LIGANDS
Title (de)
3-ARYL PYRAZOLO[4,3-D]PYRIMIDIN DERIVATE; CORTICOTROPIN AUSLÖSEFAKTOR-REZEPTOR (CRF1) SPEZIFISCHE LIGANDEN
Title (fr)
DERIVES DE PYRAZOLO[4,3-D]PYRIMIDINE A SUBSTITUTION ARYLE EN POSITION 3; LIGANDS SPECIFIQUES AU RECEPTEUR DE FACTEUR LIBERATEUR DE CORTICOTROPHINE (CRF1)
Publication
Application
Priority
- US 9724172 W 19971223
- US 77540496 A 19961231
Abstract (en)
[origin: US6211187B1] This invention encompasses compounds of the formulawhereinAr represents a mono- , di- or trisubstituted aryl group where at least one position on Ar ortho to the point of attachment to the pyrazole ring is substituted; andR1 represents lower alkyl;R2 is hydrogen or lower alkyl; andR3 and R4 independently represent organic and inorganic substituents,which compounds are highly selective partial agonists or antagonists or human CRF1 receptors and are useful in the diagnosis and treatment of treating stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety.
IPC 1-7
IPC 8 full level
A61P 25/04 (2006.01); A61K 31/519 (2006.01); A61P 25/00 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 43/00 (2006.01); C07D 487/04 (2006.01)
CPC (source: EP KR US)
A61P 25/00 (2018.01 - EP); A61P 25/04 (2018.01 - EP); A61P 25/22 (2018.01 - EP); A61P 25/24 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 487/04 (2013.01 - EP KR US)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
US 5723608 A 19980303; AT E214701 T1 20020415; AU 5811098 A 19980731; AU 738324 B2 20010913; BR 9713808 A 20000125; CA 2276610 A1 19980709; CN 1100779 C 20030205; CN 1246860 A 20000308; DE 69711241 D1 20020425; DE 69711241 T2 20021212; EP 0960110 A1 19991201; EP 0960110 B1 20020320; EP 0960110 B8 20021127; ES 2172830 T3 20021001; HK 1025958 A1 20001201; IL 130680 A0 20000601; JP 2001507705 A 20010612; KR 20000069827 A 20001125; NO 993240 D0 19990629; NO 993240 L 19990827; NZ 336529 A 20010330; US 6211187 B1 20010403; WO 9829413 A1 19980709
DOCDB simple family (application)
US 77540496 A 19961231; AT 97954301 T 19971223; AU 5811098 A 19971223; BR 9713808 A 19971223; CA 2276610 A 19971223; CN 97181857 A 19971223; DE 69711241 T 19971223; EP 97954301 A 19971223; ES 97954301 T 19971223; HK 00105113 A 20000816; IL 13068097 A 19971223; JP 53031298 A 19971223; KR 19997005989 A 19990630; NO 993240 A 19990629; NZ 33652997 A 19971223; US 34102499 A 19991022; US 9724172 W 19971223