EP 0960118 A1 19991201 - NUCLEOTIDE AND PROTEIN SEQUENCES OF LIVER ACTIVIN/INHIBIN AND METHODS BASED THEREON
Title (en)
NUCLEOTIDE AND PROTEIN SEQUENCES OF LIVER ACTIVIN/INHIBIN AND METHODS BASED THEREON
Title (de)
NUKELOTID- UND PROTEINSEQUENZEN VON LEBER-ACTIVIN/INHIBIN UND DARAUF BASIERENDE VERFAHREN
Title (fr)
SEQUENCES NUCLEOTIDIQUES ET PROTEIQUES D'ACTIVINE/INHIBINE DU FOIE ET PROCEDES AFFERENTS
Publication
Application
Priority
- US 9720882 W 19971120
- US 75291996 A 19961120
Abstract (en)
[origin: WO9822492A1] The present invention relates to the discovery, identification and characterization of a novel subgroup of activins/inhibins, herein referred to as liver activins, that during vertebrate adult life are specifically expressed in the liver. The invention relates to the activin beta C and beta E subunits and other members of the liver activin subgroup. The invention encompasses liver activin nucleotides; liver activin genomic regulatory elements that regulate the expression of liver activins; host cell expression systems; liver activin proteins, fusion proteins, polypeptides and peptides; antibodies to liver activin protein, transgenic animals that express a liver activin; recombinant knock-out animals that do not express liver activin(s); antagonists and agonists of the liver activins; and other compounds that modulate liver activin gene expression activity to regulate cell growth and/or differentiation and to diagnose and treat abnormalities related thereto. In addition, the present invention encompasses methods and compositions for the regulation of cell growth and/or differentiation including, but not limited to, stimulating liver regeneration, bone growth and hematopoiesis.
IPC 1-7
IPC 8 full level
G01N 33/53 (2006.01); A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 1/16 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 14/575 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01)
CPC (source: EP)
A61P 1/16 (2017.12); A61P 43/00 (2017.12); C07K 14/575 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9822492 A1 19980528; AU 5356798 A 19980610; AU 743792 B2 20020207; CA 2272545 A1 19980528; EP 0960118 A1 19991201; EP 0960118 A4 20010808; JP 2001505420 A 20010424
DOCDB simple family (application)
US 9720882 W 19971120; AU 5356798 A 19971120; CA 2272545 A 19971120; EP 97950609 A 19971120; JP 52376698 A 19971120