EP 0960118 A4 20010808 - NUCLEOTIDE AND PROTEIN SEQUENCES OF LIVER ACTIVIN/INHIBIN AND METHODS BASED THEREON
Title (en)
NUCLEOTIDE AND PROTEIN SEQUENCES OF LIVER ACTIVIN/INHIBIN AND METHODS BASED THEREON
Title (de)
NUKELOTID- UND PROTEINSEQUENZEN VON LEBER-ACTIVIN/INHIBIN UND DARAUF BASIERENDE VERFAHREN
Title (fr)
SEQUENCES NUCLEOTIDIQUES ET PROTEIQUES D'ACTIVINE/INHIBINE DU FOIE ET PROCEDES AFFERENTS
Publication
Application
Priority
- US 9720882 W 19971120
- US 75291996 A 19961120
Abstract (en)
[origin: WO9822492A1] The present invention relates to the discovery, identification and characterization of a novel subgroup of activins/inhibins, herein referred to as liver activins, that during vertebrate adult life are specifically expressed in the liver. The invention relates to the activin beta C and beta E subunits and other members of the liver activin subgroup. The invention encompasses liver activin nucleotides; liver activin genomic regulatory elements that regulate the expression of liver activins; host cell expression systems; liver activin proteins, fusion proteins, polypeptides and peptides; antibodies to liver activin protein, transgenic animals that express a liver activin; recombinant knock-out animals that do not express liver activin(s); antagonists and agonists of the liver activins; and other compounds that modulate liver activin gene expression activity to regulate cell growth and/or differentiation and to diagnose and treat abnormalities related thereto. In addition, the present invention encompasses methods and compositions for the regulation of cell growth and/or differentiation including, but not limited to, stimulating liver regeneration, bone growth and hematopoiesis.
IPC 1-7
IPC 8 full level
A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 1/16 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 14/575 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); G01N 33/53 (2006.01)
CPC (source: EP)
A61P 1/16 (2017.12); A61P 43/00 (2017.12); C07K 14/575 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01)
Citation (search report)
- [PX] FANG J ET AL: "GENES CODING FOR MOUSE ACTIVIN BETAC AND BETAE ARE CLOSELY LINKED AND EXIHIBIT A LIVER-SPECIFIC EXPRESSION PATTERN IN ADULT TISSUES", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,US,ACADEMIC PRESS INC. ORLANDO, FL, vol. 231, 1997, pages 655 - 661, XP000882729, ISSN: 0006-291X
- [AX] HOETTEN G ET AL: "CLONING OF A NEW MEMBER OF THE TGF-BETA FAMILY: A PUTATIVE NEW ACTIVIN BETAC CHAIN", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,US,ACADEMIC PRESS INC. ORLANDO, FL, vol. 206, no. 2, 17 January 1995 (1995-01-17), pages 608 - 613, XP000857726, ISSN: 0006-291X
- See references of WO 9822492A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9822492 A1 19980528; AU 5356798 A 19980610; AU 743792 B2 20020207; CA 2272545 A1 19980528; EP 0960118 A1 19991201; EP 0960118 A4 20010808; JP 2001505420 A 20010424
DOCDB simple family (application)
US 9720882 W 19971120; AU 5356798 A 19971120; CA 2272545 A 19971120; EP 97950609 A 19971120; JP 52376698 A 19971120