EP 0960203 A1 19991201 - MAMMALIAN CHK1 EFFECTOR CELL-CYCLE CHECKPOINT PROTEIN KINASE MATERIALS AND METHODS
Title (en)
MAMMALIAN CHK1 EFFECTOR CELL-CYCLE CHECKPOINT PROTEIN KINASE MATERIALS AND METHODS
Title (de)
CHK1 EFFEKTOR ZELLZYKLUS KONTROLLPUNKT-PROTEINKINASE AUS SÄUGETIEREN, MATERIALIEN UND METHODEN
Title (fr)
MATERIELS DE PROTEINE-KINASE POINT DE CONTROLE DU CYCLE CELLULAIRE, EFFECTEUR DE CHK1 MAMMALIEN ET METHODES
Publication
Application
Priority
- GB 9718952 A 19970905
- US 9818558 W 19980904
Abstract (en)
[origin: WO9911795A1] The present invention generally relates to genes encoding cell cycle checkpoint kinase related proteins essential to meiosis, mitosis, and DNA damage responses in cells and the respective proteins. These kinases arrest the cell cycle following DNA damage to allow DNA repair prior to mitosis, meiosis, or initiation of DNA replication. More particularly, the invention provides a novel cycle checkpoint kinase, Chkl, and polynucleotide sequences encoding Chkl. Assays for identifying modulators of Chkl are also disclosed. Modulators are useful for example, in chemotherapy and as radiation adjuvants.
IPC 1-7
C12N 15/54; C12N 15/70; C12N 9/12; C12N 1/21; C12Q 1/48; C07K 16/40
IPC 8 full level
C12N 15/09 (2006.01); C07K 16/40 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/12 (2006.01); C12N 15/54 (2006.01); C12P 21/08 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
C12N 9/1205 (2013.01)
Citation (search report)
See references of WO 9911795A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9911795 A1 19990311; AU 9223198 A 19990322; CA 2270911 A1 19990311; CN 1254377 A 20000524; EP 0960203 A1 19991201; GB 9718952 D0 19971112; GB 9723231 D0 19980107; JP 2002516577 A 20020604
DOCDB simple family (application)
US 9818558 W 19980904; AU 9223198 A 19980904; CA 2270911 A 19980904; CN 98801676 A 19980904; EP 98944772 A 19980904; GB 9718952 A 19970905; GB 9723231 A 19971103; JP 51710899 A 19980904