EP 0961782 A1 19991208 - HUMAN TUMOR NECROSIS FACTOR RECEPTOR-LIKE 2
Title (en)
HUMAN TUMOR NECROSIS FACTOR RECEPTOR-LIKE 2
Title (de)
REZEPTOR TR2 AUS DER TUMORNEKROSISFAKTOR-REZEPTOR-FAMILIE.
Title (fr)
RECEPTEUR TR2 DU FACTEUR DE NECROSE TUMORALE CHEZ L'HOMME
Publication
Application
Priority
US 9618540 W 19961030
Abstract (en)
[origin: WO9818824A1] The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.
IPC 1-7
C07K 14/715; C12N 1/20; C12N 15/12; C12N 15/87; C12N 15/63; C07H 21/04
IPC 8 full level
C12N 15/09 (2006.01); C07K 14/715 (2006.01); C07K 16/28 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/7151 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9818824 A1 19980507; WO 9818824 A9 19990930; CA 2270913 A1 19980507; CA 2270913 C 20110524; EP 0961782 A1 19991208; EP 0961782 A4 20030716; JP 2001502912 A 20010306
DOCDB simple family (application)
US 9618540 W 19961030; CA 2270913 A 19961030; EP 96942776 A 19961030; JP 52041398 A 19961030