Global patent index - EP 0963434 A4

EP 0963434 A4 2000-10-25 - METHODS FOR OPTIMIZATION OF GENE THERAPY BY RECURSIVE SEQUENCE SHUFFLING AND SELECTION

Title (en)

METHODS FOR OPTIMIZATION OF GENE THERAPY BY RECURSIVE SEQUENCE SHUFFLING AND SELECTION

Title (de)

METHODEN ZUR OPTIMIERUNG DER GENTHERAPIE MITTELS REKURSIVEN SEQUENZSHUFFLINGS UND SELEKTION

Title (fr)

PROCEDES PERMETTANT L'OPTIMISATION DE LA THERAPIE GENIQUE GRACE A UN REARRANGEMENT ET UNE SELECTION RECURSIFS DE SEQUENCES

Publication

EP 0963434 A4 (EN)

Application

EP 97944487 A

Priority

  • US 3774296 P
  • US 9717302 W

Abstract (en)

[origin: WO9813485A1] The invention provides methods of evolving nucleic acids for use in gene therapy by recursive sequence recombination. Many of the methods evolve vectors, both viral and nonviral, to have improved properties. For example, vectors are evolved to have improved properties of viral titer, infectivity, expression of a gene within a vector, tissue specificity, viral genome capacity, episomal retention, lack of immunogenicity of the vectors or an expression product thereof, site-specific integration, increased stability, or capacity to confer cellular resistance to microorganism infection. The invention further provides an isolated O<6>-methylguanine-DNA methyltransferase (MGMT) enzyme.

IPC 1-7 (main, further and additional classification)

C12N 15/00; C12Q 1/68

IPC 8 full level (invention and additional information)

A61K 38/45 (2006.01); A61K 48/00 (2006.01); C07K 14/47 (2006.01); C12N 7/00 (2006.01); C12N 9/10 (2006.01); C12N 15/10 (2006.01)

CPC (invention and additional information)

C12N 15/10 (2013.01); A61K 38/45 (2013.01); A61K 48/00 (2013.01); C07K 14/47 (2013.01); C12N 7/00 (2013.01); C12N 9/1007 (2013.01); C12N 15/1058 (2013.01); C12N 2710/10343 (2013.01); C12N 2795/18143 (2013.01)

Citation (search report)

  • No further relevant documents disclosed
  • See also references of WO 9813485A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9813485 A1 19980402; AU 4597197 A 19980417; CA 2268265 A1 19980402; EP 0963434 A1 19991215; EP 0963434 A4 20001025

INPADOC legal status

2002-07-31 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20020115

2001-10-24 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20010905

2000-10-25 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20000907

2000-10-25 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

1999-12-15 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19990415

1999-12-15 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE