Global Patent Index - EP 0963434 A4

EP 0963434 A4 20001025 - METHODS FOR OPTIMIZATION OF GENE THERAPY BY RECURSIVE SEQUENCE SHUFFLING AND SELECTION

Title (en)

METHODS FOR OPTIMIZATION OF GENE THERAPY BY RECURSIVE SEQUENCE SHUFFLING AND SELECTION

Title (de)

METHODEN ZUR OPTIMIERUNG DER GENTHERAPIE MITTELS REKURSIVEN SEQUENZSHUFFLINGS UND SELEKTION

Title (fr)

PROCEDES PERMETTANT L'OPTIMISATION DE LA THERAPIE GENIQUE GRACE A UN REARRANGEMENT ET UNE SELECTION RECURSIFS DE SEQUENCES

Publication

EP 0963434 A4 20001025 (EN)

Application

EP 97944487 A 19970926

Priority

  • US 3774296 P 19960927
  • US 9717302 W 19970926

Abstract (en)

[origin: WO9813485A1] The invention provides methods of evolving nucleic acids for use in gene therapy by recursive sequence recombination. Many of the methods evolve vectors, both viral and nonviral, to have improved properties. For example, vectors are evolved to have improved properties of viral titer, infectivity, expression of a gene within a vector, tissue specificity, viral genome capacity, episomal retention, lack of immunogenicity of the vectors or an expression product thereof, site-specific integration, increased stability, or capacity to confer cellular resistance to microorganism infection. The invention further provides an isolated O<6>-methylguanine-DNA methyltransferase (MGMT) enzyme.

IPC 1-7

C12N 15/00; C12Q 1/68

IPC 8 full level

A61K 38/45 (2006.01); A61K 48/00 (2006.01); C07K 14/47 (2006.01); C12N 7/00 (2006.01); C12N 9/10 (2006.01); C12N 15/10 (2006.01)

CPC (source: EP)

A61K 38/45 (2013.01); A61K 48/00 (2013.01); C07K 14/47 (2013.01); C12N 7/00 (2013.01); C12N 9/1007 (2013.01); C12N 15/10 (2013.01); C12N 15/1058 (2013.01); C12N 2710/10343 (2013.01); C12N 2795/18143 (2013.01)

Citation (search report)

  • No further relevant documents disclosed
  • See references of WO 9813485A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9813485 A1 19980402; AU 4597197 A 19980417; CA 2268265 A1 19980402; EP 0963434 A1 19991215; EP 0963434 A4 20001025

DOCDB simple family (application)

US 9717302 W 19970926; AU 4597197 A 19970926; CA 2268265 A 19970926; EP 97944487 A 19970926