EP 0963440 A4 20041229 - IMPROVED METHODS FOR TRANSDUCING CELLS
Title (en)
IMPROVED METHODS FOR TRANSDUCING CELLS
Title (de)
VERBESSERTES VERFAHREN ZUR TRANSDUKTION VON ZELLEN
Title (fr)
METHODES AMELIOREES DE TRANSDUCTION CELLULAIRE
Publication
Application
Priority
- US 9721475 W 19971119
- US 3133096 P 19961120
Abstract (en)
[origin: WO9822605A1] Disclosed are compositions and methods for inhibiting the expression and/or activity of endogenous beta -interferon in cells targeted for transduction with viral vectors, particularly adenoviral vectors. Therefore, also provided are improved methods for treatment of genetically-based diseases by gene therapy. Also disclosed are methods for the treatment of neovascularization-related diseases, for examples, cancer, by the production in vivo of angiostatin, which inhibits the formation of new blood vessels. In particular embodiments, this is accomplished by transduction of macrophages ex vivo with a GM-CSF gene, thereby inducing the secretion of macrophage metalloelastase, which converts plasminogen to angiostatin. The transduced macrophages, when administered, naturally home to tumor sites to effectively localize the therapeutic effect.
IPC 1-7
IPC 8 full level
A61K 31/7088 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 38/19 (2006.01); A61K 38/48 (2006.01); A61K 38/55 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); C07K 14/47 (2006.01); C07K 14/565 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01)
CPC (source: EP)
A61K 38/193 (2013.01); A61K 48/00 (2013.01); A61P 35/00 (2017.12); A61P 37/00 (2017.12); C07K 14/4702 (2013.01); C07K 14/565 (2013.01); C12N 2799/022 (2013.01)
Citation (search report)
- [X] DE 4442587 A1 19960801 - BOEHRINGER INGELHEIM INT [DE]
- [X] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1992, LALLEMAND C ET AL: "AN ANTISENSE INTERFERON-BETA RNA ABOLISHES REPRESSION OF C-FOS GENE EXPRESSION", XP002283638, Database accession no. PREV199294039408 & ONCOGENE, vol. 7, no. 6, 1992, pages 1109 - 1118, ISSN: 0950-9232
- [X] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1994, NICKOLAUS PETER ET AL: "Inhibition by interleukin-4 of constitutive beta interferon synthesis in mouse macrophages", XP002283639, Database accession no. PREV199497512589 & JOURNAL OF VIROLOGY, vol. 68, no. 10, 1994, pages 6763 - 6766, ISSN: 0022-538X
- [A] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1992, NIELSCH U ET AL: "INDUCED EXPRESSION OF THE ENDOGENOUS BETA INTERFERON GENE IN ADENOVIRUS TYPE 5-TRANSFORMED RAT FIBROBLASTS", XP002285025, Database accession no. PREV199293135844 & JOURNAL OF VIROLOGY, vol. 66, no. 4, 1992, pages 1884 - 1890, ISSN: 0022-538X
- [A] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1988, SHIROKI K ET AL: "ACTIVATION OF THE HUMAN BETA INTERFERON GENE BY THE ADENOVIRUS TYPE 12 E1B GENE", XP002285026, Database accession no. PREV198885057675 & JOURNAL OF VIROLOGY, vol. 62, no. 1, 1988, pages 325 - 330, ISSN: 0022-538X
- [PX] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1997, DONG ZHONGYUN ET AL: "Neutralization of endogenous interferon-beta increases the efficiency of adenoviral vector-mediated gene transduction", XP002283640, Database accession no. PREV199799707380 & JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, vol. 17, no. 7, 1997, pages 401 - 407, ISSN: 1079-9907
- See references of WO 9822605A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9822605 A1 19980528; CA 2275438 A1 19980528; EP 0963440 A1 19991215; EP 0963440 A4 20041229; JP 2001505205 A 20010417
DOCDB simple family (application)
US 9721475 W 19971119; CA 2275438 A 19971119; EP 97950669 A 19971119; JP 52395398 A 19971119