EP 0964617 A1 19991222 - STRUCTURE-BASED RATIONAL DESIGN OF COMPOUNDS TO INHIBIT PAPILLOMAVIRUS INFECTION
Title (en)
STRUCTURE-BASED RATIONAL DESIGN OF COMPOUNDS TO INHIBIT PAPILLOMAVIRUS INFECTION
Title (de)
AUF DER STRUKTUR BASIERENDER RATIONALER ENTWURF VON VERBINDUNGEN ZUR HEMMUNG DER PAPILLOMAVIRUSINFEKTION
Title (fr)
CONCEPTION RATIONNELLE DE COMPOSES PERMETTANT DE LUTTER CONTRE LES INFECTIONS PAR PAPILLOMAVIRUS, FONDEE SUR LEUR STRUCTURE
Publication
Application
Priority
- US 9820991 W 19981006
- US 6129597 P 19971007
Abstract (en)
[origin: WO9917616A1] The invention provides methods of evaluating a compound for the ability to interact with the HPV E6 transforming protein. The invention also provides a machine-readable data storage medium, comprising a data storage material encoded with a set of NMR derived coordinates which define the three-dimensional structure of the E6bp molecule as well as a machine-readable data storage medium, comprising a data storage material encoded with machine readable data which, when used with a machine programmed with instructions for using the data, is capable of displaying a graphical three-dimensional representation of the E6bp molecule. The invention further provides a method of treating a subject at risk for infection by a HPV. A compound having a three-dimensional structure substantially similar to the three-dimensional structure of E6bp and a composition comprising the candidate compound and a carrier macromolecule are also provided. Finally a method of evaluating the ability of a compound to associate with an E6bp molecule is provided.
IPC 1-7
IPC 8 full level
G01N 33/566 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61P 31/20 (2006.01); C07K 14/00 (2006.01); C07K 14/02 (2006.01); C07K 14/025 (2006.01); G01N 33/569 (2006.01); G06F 17/30 (2006.01)
CPC (source: EP)
A61P 31/20 (2017.12); C07K 14/001 (2013.01); C07K 14/005 (2013.01); G01N 33/56983 (2013.01); C12N 2730/10122 (2013.01)
Citation (search report)
See references of WO 9917616A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9917616 A1 19990415; AU 1067699 A 19990427; CA 2273186 A1 19990415; EP 0964617 A1 19991222; JP 2001513823 A 20010904
DOCDB simple family (application)
US 9820991 W 19981006; AU 1067699 A 19981006; CA 2273186 A 19981006; EP 98953264 A 19981006; JP 52222399 A 19981006