EP 0964848 A4 20040804 - PREPARATION OF ALPHA-AMINO CARBOXYLIC ACID AMIDES
Title (en)
PREPARATION OF ALPHA-AMINO CARBOXYLIC ACID AMIDES
Title (de)
HERSTELLUNG VON ALPHA-AMINO-CARBONSAEUREAMIDEN
Title (fr)
PREPARATION D'AMIDES DE L'ACIDE ALPHA-AMINO-CARBOXYLIQUE
Publication
Application
Priority
- US 9724066 W 19971222
- US 78481897 A 19970116
Abstract (en)
[origin: WO9831657A1] Method of preparing alpha -amino carboxylic acid amides directly from aminonitriles in high yield and purity by acid hydrolysis. The method involves preparing the amide salt such as amide hydrochloride directly from the corresponding aminonitrile in the presence of water, a strong mineral acid such as anhydrous HCl, and an organic solvent in which the resulting amide salt is insoluble or substantially insoluble. Suitable organic solvents include dialkyl ethers, dialkyl ethylene glycol ethers and secondary alcohols.
IPC 1-7
IPC 8 full level
C07C 231/06 (2006.01); C07C 237/06 (2006.01); C07C 237/24 (2006.01)
CPC (source: EP KR)
C07C 231/06 (2013.01 - EP KR); C07C 2601/08 (2017.04 - EP)
Citation (search report)
- [Y] US 4017510 A 19770412 - LOS MARINUS
- [DY] JOHNSON H.E. ET AL: "alpha-Amino acid amides. A convenient synthesis", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 27, no. 3, 1962, pages 798 - 802, XP002119422, ISSN: 0022-3263
- [Y] MATESANZ E. ET AL.: "Synthesis, structural and conformational study of some amides derived from 3,7-dimethyl-9-amino-3,7-diazabicyclo (3.3.1) nonane-9-carboxamide", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 29, no. 4, 1992, USHETEROCORPORATION. PROVO., pages 723 - 740, XP002284044
- [Y] DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002284045 & JUSTUS LIEBIGS ANNALEN DER CHEMIE., vol. 177, 1875, DEVERLAG CHEMIE GMBH. WEINHEIM., pages 103
- See references of WO 9831657A1
Designated contracting state (EPC)
DE ES FR GB IT NL
DOCDB simple family (publication)
WO 9831657 A1 19980723; AU 5723998 A 19980807; AU 728197 B2 20010104; BR 9714185 A 20000229; CA 2274527 A1 19980723; CN 1244858 A 20000216; DE 964848 T1 20010208; EP 0964848 A1 19991222; EP 0964848 A4 20040804; ES 2143445 T1 20000516; IN 187448 B 20020427; JP 2001508073 A 20010619; KR 20000070259 A 20001125; ZA 98115 B 19980709
DOCDB simple family (application)
US 9724066 W 19971222; AU 5723998 A 19971222; BR 9714185 A 19971222; CA 2274527 A 19971222; CN 97181422 A 19971222; DE 97953506 T 19971222; EP 97953506 A 19971222; ES 97953506 T 19971222; IN 9DE1998 A 19980102; JP 53336598 A 19971222; KR 19997006487 A 19990716; ZA 98115 A 19980107