EP 0964853 A1 19991222 - 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS
Title (en)
4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS
Title (de)
4-AMINOALKOXY-1,3-DIHYDROBENZIMIDAZOL-2-ON DERIVATE, DEREN HERSTELLUNG UNDDEREN VERWENDUNG ALS DOPAMIN AUTOREZEPTOR (D2) AGONISTEN
Title (fr)
DERIVES 4-AMINOALCOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONES, LEUR PREPARATION ET LEUR UTILISATION COMME AGONISTES DE L'AUTORECEPTEUR DE LA DOPAMINE (D2)
Publication
Application
Priority
- US 9800623 W 19980113
- US 80187097 A 19970218
Abstract (en)
[origin: WO9835946A1] Disclosed are compounds of formula (I), wherein R<1> is hydrogen or C1-C6 alkyl; R<2> is selected from hydrogen, straight-chain and branched C1-C10 alkyl, cyclohexylmethyl or -(CH2)mAr where Ar is phenyl, naphthyl, thienyl, furanyl or pyridinyl, each optionally substituted by one or two substituents selected independently from C1-C6 alkyl, halogen, C1-C6 alkoxy and trifluoromethyl; or NR<1>R<2> is 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4-tetrahydroisoquinolin-2-yl; m is 1-5; n is 1 or 2; R<3> is hydrogen or C1-C6 alkyl; Y is halogen, C1-C6 alkyl, and C1-C6 alkoxy; or a pharmaceutically acceptable salt thereof, which are dopamine autoreceptor agonists and as such are useful in the treatment of schizophrenia, Parkinson's disease, Tourette's syndrome, alcohol addiction and drug addiction.
IPC 1-7
C07D 235/26; A61K 31/415; C07D 409/12; C07D 401/12; A61K 31/47
IPC 8 full level
A61K 31/4184 (2006.01); A61K 31/4725 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/30 (2006.01); C07D 235/26 (2006.01); C07D 401/12 (2006.01); C07D 409/12 (2006.01)
CPC (source: EP KR)
A61P 25/16 (2018.01 - EP); A61P 25/18 (2018.01 - EP); A61P 25/30 (2018.01 - EP); C07D 235/26 (2013.01 - EP KR); C07D 401/12 (2013.01 - EP); C07D 409/12 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9835946 A1 19980820; AR 011138 A1 20000802; AU 6023498 A 19980908; AU 744443 B2 20020221; BR 9807703 A 20000502; CA 2278747 A1 19980820; CN 1138761 C 20040218; CN 1252060 A 20000503; EP 0964853 A1 19991222; HU P0001262 A2 20010428; HU P0001262 A3 20020429; IL 131156 A0 20010128; JP 2001511804 A 20010814; KR 20000071160 A 20001125; NZ 337271 A 20010126; TW 383303 B 20000301; ZA 981310 B 19990817
DOCDB simple family (application)
US 9800623 W 19980113; AR P980100620 A 19980211; AU 6023498 A 19980113; BR 9807703 A 19980113; CA 2278747 A 19980113; CN 98804119 A 19980113; EP 98903469 A 19980113; HU P0001262 A 19980113; IL 13115698 A 19980113; JP 53572998 A 19980113; KR 19997007450 A 19990817; NZ 33727198 A 19980113; TW 87101495 A 19980205; ZA 981310 A 19980217