EP 0964853 A1 19991222 - 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS
Title (en)
4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS
Title (de)
4-AMINOALKOXY-1,3-DIHYDROBENZIMIDAZOL-2-ON DERIVATE, DEREN HERSTELLUNG UNDDEREN VERWENDUNG ALS DOPAMIN AUTOREZEPTOR (D2) AGONISTEN
Title (fr)
DERIVES 4-AMINOALCOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONES, LEUR PREPARATION ET LEUR UTILISATION COMME AGONISTES DE L'AUTORECEPTEUR DE LA DOPAMINE (D2)
Publication
Application
Priority
- US 9800623 W 19980113
- US 80187097 A 19970218
Abstract (en)
[origin: WO9835946A1] Disclosed are compounds of formula (I), wherein R<1> is hydrogen or C1-C6 alkyl; R<2> is selected from hydrogen, straight-chain and branched C1-C10 alkyl, cyclohexylmethyl or -(CH2)mAr where Ar is phenyl, naphthyl, thienyl, furanyl or pyridinyl, each optionally substituted by one or two substituents selected independently from C1-C6 alkyl, halogen, C1-C6 alkoxy and trifluoromethyl; or NR<1>R<2> is 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4-tetrahydroisoquinolin-2-yl; m is 1-5; n is 1 or 2; R<3> is hydrogen or C1-C6 alkyl; Y is halogen, C1-C6 alkyl, and C1-C6 alkoxy; or a pharmaceutically acceptable salt thereof, which are dopamine autoreceptor agonists and as such are useful in the treatment of schizophrenia, Parkinson's disease, Tourette's syndrome, alcohol addiction and drug addiction.
IPC 1-7
C07D 235/26; A61K 31/415; C07D 409/12; C07D 401/12; A61K 31/47
IPC 8 full level
A61K 31/4184 (2006.01); A61K 31/4725 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/30 (2006.01); C07D 235/26 (2006.01); C07D 401/12 (2006.01); C07D 409/12 (2006.01)
CPC (source: EP KR)
A61P 25/16 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/30 (2017.12 - EP); C07D 235/26 (2013.01 - EP KR); C07D 401/12 (2013.01 - EP); C07D 409/12 (2013.01 - EP)
Citation (search report)
See references of WO 9835946A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9835946 A1 19980820; AR 011138 A1 20000802; AU 6023498 A 19980908; AU 744443 B2 20020221; BR 9807703 A 20000502; CA 2278747 A1 19980820; CN 1138761 C 20040218; CN 1252060 A 20000503; EP 0964853 A1 19991222; HU P0001262 A2 20010428; HU P0001262 A3 20020429; IL 131156 A0 20010128; JP 2001511804 A 20010814; KR 20000071160 A 20001125; NZ 337271 A 20010126; TW 383303 B 20000301; ZA 981310 B 19990817
DOCDB simple family (application)
US 9800623 W 19980113; AR P980100620 A 19980211; AU 6023498 A 19980113; BR 9807703 A 19980113; CA 2278747 A 19980113; CN 98804119 A 19980113; EP 98903469 A 19980113; HU P0001262 A 19980113; IL 13115698 A 19980113; JP 53572998 A 19980113; KR 19997007450 A 19990817; NZ 33727198 A 19980113; TW 87101495 A 19980205; ZA 981310 A 19980217