EP 0964854 A1 19991222 - 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-THIONES DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS
Title (en)
4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-THIONES DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS
Title (de)
4-AMINOALKOXY-1,3-DIHYDROBENZIMIDAZOL-2-THION DERIVATE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS DOPAMIN AUTOREZEPTOR (D2) AGONISTEN
Title (fr)
DERIVES DE 4-AMINOALCOXY-1,3-DIHYDROBENZOIMIDAZOL-2-THIONES, LEUR PREPARATION ET LEUR UTILISATION EN TANT QU'AGONISTES D'AUTORECEPTEUR DE LA DOPAMINE (D2)
Publication
Application
Priority
- US 9800612 W 19980113
- US 80265197 A 19970218
Abstract (en)
[origin: WO9835947A1] This invention relates to a novel series of compounds having potency at the dopamine D2 receptor which are illustrated by formula (I) wherein R<1> is hydrogen or C1-C6 alkyl; R<2> is hydrogen or C1-C6 alkyl; R<3> is selected from hydrogen, straight-chain and branched alkyl group having up to 10 carbon atoms, cyclohexylmethyl or -(CH2)mAr where Ar is phenyl, naphthyl, thienyl, furanyl or pyridinyl, each optionally substituted by one or two substituents selected independently from C1-C6 alkyl, halogen, C1-C6 alkoxy and trifluoromethyl; or NR<2>R<3> is 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4-tetrahydroisoquinolin-2-yl; m is 1-5; n is 1 or 2; Y is halogen, C1-C6 alkyl, and C1-C6 alkoxy; or a pharmaceutically acceptable salt thereof.
IPC 1-7
C07D 235/28; A61K 31/415; C07D 409/12; C07D 401/12; A61K 31/47
IPC 8 full level
A61K 31/4184 (2006.01); A61K 31/4725 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/30 (2006.01); C07D 235/28 (2006.01); C07D 401/12 (2006.01); C07D 409/12 (2006.01)
CPC (source: EP KR)
A61P 25/00 (2018.01 - EP); A61P 25/16 (2018.01 - EP); A61P 25/18 (2018.01 - EP); A61P 25/30 (2018.01 - EP); C07D 235/28 (2013.01 - EP KR); C07D 401/12 (2013.01 - EP); C07D 409/12 (2013.01 - EP); H04N 19/126 (2014.11 - EP); H04N 19/154 (2014.11 - EP); H04N 19/172 (2014.11 - EP); H04N 19/182 (2014.11 - EP); H04N 19/61 (2014.11 - EP); H04N 19/85 (2014.11 - EP); H04N 19/124 (2014.11 - EP); H04N 19/132 (2014.11 - EP); H04N 19/146 (2014.11 - EP); H04N 19/149 (2014.11 - EP); H04N 19/15 (2014.11 - EP); H04N 19/152 (2014.11 - EP); H04N 19/60 (2014.11 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9835947 A1 19980820; AR 011139 A1 20000802; AU 5915298 A 19980908; BR 9807840 A 20000919; CA 2278718 A1 19980820; CN 1252061 A 20000503; EP 0964854 A1 19991222; HU P0001942 A2 20001128; IL 131157 A0 20010128; JP 2001511803 A 20010814; KR 20000071124 A 20001125; ZA 981308 B 19990817
DOCDB simple family (application)
US 9800612 W 19980113; AR P980100621 A 19980211; AU 5915298 A 19980113; BR 9807840 A 19980113; CA 2278718 A 19980113; CN 98804120 A 19980113; EP 98902512 A 19980113; HU P0001942 A 19980113; IL 13115798 A 19980113; JP 53572698 A 19980113; KR 19997007412 A 19990816; ZA 981308 A 19980113