Global Patent Index - EP 0966478 A4

EP 0966478 A4 20020821 - NOVEL HEDGEHOG-DERIVED POLYPEPTIDES

Title (en)

NOVEL HEDGEHOG-DERIVED POLYPEPTIDES

Title (de)

NEUE VOM IGEL ABSTAMMENDE POLYPEPTIDE

Title (fr)

NOUVEAUX POLYPEPTIDES DERIVES D'UNE PROTEINE HERISSON

Publication

EP 0966478 A4 20020821 (EN)

Application

EP 97910705 A 19971007

Priority

  • US 9715753 W 19971007
  • US 72974396 A 19961007
  • US 6132397 P 19971002

Abstract (en)

[origin: WO9830576A1] The present invention provides two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G &darr& CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

IPC 1-7

C07K 1/00; C07K 14/435; C07K 14/46; C07K 14/47

IPC 8 full level

G01N 33/53 (2006.01); C07K 14/435 (2006.01); C07K 14/46 (2006.01); C07K 14/47 (2006.01); C12N 15/09 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

C07K 14/43581 (2013.01); C07K 14/46 (2013.01); C07K 14/47 (2013.01); G01N 33/5008 (2013.01); G01N 33/5011 (2013.01); G01N 33/502 (2013.01); G01N 33/5058 (2013.01); G01N 33/5091 (2013.01); G01N 33/68 (2013.01); A61K 38/00 (2013.01); C07K 2319/21 (2013.01); C07K 2319/23 (2013.01); C07K 2319/50 (2013.01); G01N 2333/43573 (2013.01); G01N 2333/4603 (2013.01); G01N 2333/4606 (2013.01); G01N 2333/465 (2013.01); G01N 2333/47 (2013.01); G01N 2500/10 (2013.01)

Citation (search report)

  • [X] WO 9616668 A1 19960606 - UNIV JOHNS HOPKINS MED [US], et al
  • [A] EP 0020029 A1 19801210 - ARUBA PTY LTD [AU]
  • [X] PORTER ET AL: "Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 86, 12 July 1996 (1996-07-12), pages 21 - 34, XP002082039, ISSN: 0092-8674
  • [PX] PORTER ET AL: "Cholesterol modification of hedgehog signaling proteins in animal development", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 274, 11 October 1996 (1996-10-11), pages 255 - 259, XP002082038, ISSN: 0036-8075
  • [DX] LANGE Y ET AL: "CHOLESTEROL HOMEOSTASIS MODULATION BY AMPHIPHILES", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 269, no. 47, 25 November 1994 (1994-11-25), pages 29371 - 29374, XP000971919, ISSN: 0021-9258
  • See references of WO 9830576A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9830576 A1 19980716; AU 4800697 A 19980803; AU 728541 B2 20010111; CA 2267106 A1 19980716; EP 0966478 A1 19991229; EP 0966478 A4 20020821; IL 129295 A0 20000217; JP 2002503088 A 20020129

DOCDB simple family (application)

US 9715753 W 19971007; AU 4800697 A 19971007; CA 2267106 A 19971007; EP 97910705 A 19971007; IL 12929597 A 19971007; JP 52494798 A 19971007