Global Patent Index - EP 0968190 A1

EP 0968190 A1 2000-01-05 - SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS

Title (en)

SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS

Title (de)

SUBSTITUIERTE ISOCHINOLINE DERIVATE UND IHRE VERWENDUNG ALS ANTICONVULSIVA

Title (fr)

DERIVES D'ISOQUINOLINE SUBSTITUEE ET LEUR UTILISATION EN TANT QU'ANTICONVULSIVANTS

Publication

EP 0968190 A1 (EN)

Application

EP 98909647 A

Priority

  • GB 9800782 W
  • GB 9705619 A
  • GB 9726695 A

Abstract (en)

[origin: WO9841508A1] Compounds of formula (I) and pharmaceutically acceptable salts thereof; where Q is a monocyclic or bicyclic aryl or heteroaryl ring, R<1> is hydrogen, C1-6alkyl (optionally substituted by hydroxy or C1-4alkoxy), C1-6alkenyl, C1-6alkynyl, C1-6alkylCO-, formyl, CF3CO- or C1-6alkylSO2-, R<2> is hydrogen or up to three substituents selected from halogen, NO2, CN, N3, CF3O-, CF3S-, CF3CO-, trifluoromethyldiazirinyl, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6perfluoroalkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO-, C1-6alkylCO-, C3-6cycloalkylO-, C3-6cycloalkylCO-, C3-6cycloalkyl-C1-4alkylO-, C3-6cycloalkyl-C1-4alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, C1-6alkylS-, C1-6alkylSO2-, (C1-4alkyl)2NSO2-, (C1-4alkyl)NHSO2-, (C1-4alkyl)2NCO-, (C1-4alkyl)NHCO- or CONH2; or -NR<3>R<4> where R<3> is hydroven or C1-4alkyl, and R<4> is hydrogen, C1-4alkyl, formyl, -CO2C1-4alkyl or -COC1-4alkyl; or two R<2> groups together form a carbocyclic ring that is saturated or unsaturated and unsubstituted or substituted by -OH or =O; and X is hydrogen, halogen, C1-6alkoxy, C1-6alkyl, amino or trifluoroacetylamino, but when X is hydrogen excluding compounds in which R<2> is 2-alkoxy and when X is hydrogen excluding the compounds N-(7-iodo-2-methyl-1,2,3,4-tetrahydroisoquinolin-5-yl) -5-benzoyl-2-methoxybenzamide, N-(7-iodo-1,2,3,4-tetrahydroisoquinolin-5-yl) -5-benzoyl-2-methoxybenzamide, N-(5-iodo-1,2,3,4-tetrahydroisoquinolin-7-yl) -5-benzoyl-2-methoxybenzamide, N-(5-iodo-1,2,3,4-tetrahydroisoquinolin-7-yl) -2-methoxy-4-trifluoromethyldiazirinylbenzamide, N-(5-iodo-1,2,3,4-tetrahydroisoquinolin-7-yl) -2-methoxy-5-trifluoromethyldiazirinylbenzamide, N-(7-iodo-1,2,3,4,-tetrahydroisoquinolin-5-yl) -2-methoxy-5-trifluoromethyldiazirinylbenzamide et N-(8-fluoro-2-methyl-1,2,3,4-tetrahydroisoquinolin-5-yl) -4-t-butyl-2-methoxybenzamide, are useful inter alia in the treatment and prophylaxis of epilepsy.

IPC 1-7

C07D 217/04; A61K 31/47; C07D 217/02; C07D 217/06; C07D 401/12; C07D 405/12; C07D 409/12; C07D 413/12; C07D 417/12

IPC 8 full level

A61P 25/04 (2006.01); A61K 31/472 (2006.01); A61K 31/4725 (2006.01); A61P 3/10 (2006.01); A61P 21/00 (2006.01); A61P 21/02 (2006.01); A61P 25/06 (2006.01); A61P 25/08 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); C07D 217/02 (2006.01); C07D 217/04 (2006.01); C07D 217/06 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01)

CPC

C07D 401/12 (2013.01); C07D 217/02 (2013.01); C07D 217/04 (2013.01); C07D 217/06 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01)

Citation (search report)

See references of WO 9841508A1

DCS

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family

WO 9841508 A1 19980924; AR 012092 A1 20000927; AU 6412898 A 19981012; AU 737955 B2 20010906; BR 9809047 A 20000801; CA 2284218 A1 19980924; CN 1183116 C 20050105; CN 1255124 A 20000531; CO 4950553 A1 20000901; EP 0968190 A1 20000105; IL 131756 D0 20010319; JP 2001515504 A 20010918; JP 3690423 B2 20050831; KR 100568654 B1 20060407; KR 20000076342 A 20001226; NO 314081 B1 20030127; NO 994510 D0 19990917; NO 994510 L 19990917; NZ 337424 A 20010831; PL 192116 B1 20060831; PL 335676 A1 20000508; TR 199902283 T2 19991221; TW 555694 B 20031001