EP 0968199 A1 20000105 - ANTIBACTERIAL HETEROCYCLIC AMINO ACID DERIVATIVES
Title (en)
ANTIBACTERIAL HETEROCYCLIC AMINO ACID DERIVATIVES
Title (de)
ANTIBAKTERIELLE HETEROCYCLISCHE AMINOSÄUREDERIVATE
Title (fr)
DERIVES D'ACIDE AMINE HETEROCYCLIQUE ANTIBACTERIEN
Publication
Application
Priority
- EP 9801278 W 19980225
- GB 9704522 A 19970305
Abstract (en)
[origin: WO9839311A1] A method of treatment of bacterial infections in humans or animals which comprises administering, in combination with a beta -lactam antibiotic, a therapeutically effective amount of an amino acid derivative or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof: (i) or (ii), wherein X is S, S(O)p or CH2 where p is 1 or 2; R is hydrogen, a salt forming cation or an in vivo hydrolysable ester-forming group; R1 and R2 are selected from halogen, mercapto, (C1-6)alkyl optionally substituted by 1-3 halo, phenyl, (C1-6)alkoxy optionally substituted by 1-3 halo, hydroxy(C1-6)alkyl, mercapto(C1-6)alkyl, hydroxy, CO2R7, N(R7)2 or CON(R7)2 where each R7 is independently hydrogen or (C1-6)alkyl, OCONH2, nitro, (C1-6)alkylcarbonyloxy, (C1-6)alkoxycarbonyl(C1-6)alkyl, formyl, or (C1-6)alkylcarbonyl groups; R3 is hydrogen, (C1-6)alkyl optionally substituted by up to three halogen atoms, (C3-7)cycloalkyl, fused aryl(C3-7)cycloalkyl, (C3-7)cycloalkyl(C2-6)alkyl, (C2-6)alkenyl, (C2-6)alkynyl, aryl, aryl-(CHR10)m-X1-(CHR11)n, heterocyclyl or heterocyclyl-(CHR10)m-X1-(CHR11)n, where m is 0 to 3, n is 1 to 3, each R10 and R11 is independently hydrogen or (C1-4)alkyl and X1 is O, S(O)x where x is 0-2, or a bond; R4 is hydrogen, or an in vivo hydrolysable acyl group; and R5 and R6 are independently hydrogen and (C1-6)alkyl or together represent (CH2)q where q is 2 to 5.
IPC 1-7
C07D 279/06; C07D 211/60; C07D 217/26; A61K 31/54; A61K 31/445; A61K 31/47
IPC 8 full level
A61K 31/445 (2006.01); A61K 31/47 (2006.01); A61K 31/472 (2006.01); A61K 31/54 (2006.01); A61P 31/04 (2006.01); A61P 43/00 (2006.01); C07D 211/60 (2006.01); C07D 217/26 (2006.01); C07D 279/06 (2006.01); C07D 279/08 (2006.01)
CPC (source: EP)
A61K 31/445 (2013.01); A61K 31/47 (2013.01); A61K 31/541 (2013.01); A61P 31/04 (2017.12); A61P 43/00 (2017.12); C07D 211/60 (2013.01); C07D 217/26 (2013.01); C07D 279/06 (2013.01); Y02A 50/30 (2017.12)
Citation (search report)
See references of WO 9839311A1
Designated contracting state (EPC)
BE CH DE ES FR GB IT LI NL
DOCDB simple family (publication)
WO 9839311 A1 19980911; CA 2282691 A1 19980911; EP 0968199 A1 20000105; GB 9704522 D0 19970423; JP 2001515477 A 20010918
DOCDB simple family (application)
EP 9801278 W 19980225; CA 2282691 A 19980225; EP 98913662 A 19980225; GB 9704522 A 19970305; JP 53816798 A 19980225