Title (en)

PROCESS FOR THE PREPARATION OF 2- (2-PYRIDINYL)METHYL SULFINYL -1H-BENZIMIDAZOLES AND NOVEL COMPOUNDS OF USE FOR SUCH PURPOSE

Title (de)

VERFAHREN ZUR HERSTELLUNG VON 2-¬¬(2-PYRIDINYL)METHYL SULFINYL -1H-BENZIMIDAZOLEN UND DABEI VERWENDBARE NEUE VERBINDUNGEN

Title (fr)

PROCEDE DE PREPARATION DE 2- 2-PYRIDINYL)METHYL SULFYNYL -1H-BENZIMIDAZOLES ET NOUVEAUX COMPOSES A UTILISER DANS LEDIT PROCEDE

Publication

EP 0968204 A1 20000105 (EN)

Application

EP 98902960 A 19980216

Priority

• DK 9800058 W 19980216
• DK 25197 A 19970307

Abstract (en)

[origin: WO9840377A1] A process for the preparation of 2-[[2-pyridinyl)methyl]sulfinyl]-1-H-benzimidazole derivatives of general formula (I), wherein R<2> represents H, OCH3, OCHF2 or CF3; R<3> represents H, CH3 or OCH3; R<4> represents H, OCH3, OCH2CF3, or halo, such as Cl, Br or F; and R<5> represents H, CH3 or OCH3, or salts thereof, comprising reducing a compound of general formula (II) or a salt thereof wherein R<2>, R<3>, R<4> and R<5> are as defined above, in an alcoholic solvent, the reduction being carried out using a thiobisamine as reducing agent in the presence of a mineral acid, and, if desired, converting a compound obtained in free form into a salt thereof, or vice versa, and novel intermediates of formula (II) are described. The compounds of formula (I) are biologically active and/or may be of use as intermediates in the synthesis of biologically active compounds.

IPC 1-7

C07D 401/12

IPC 8 full level

C07D 401/12 (2006.01)

CPC (source: EP)

C07D 401/12 (2013.01)

Citation (search report)

See references of WO 9840377A1

Designated contracting state (EPC)

DE DK FI

DOCDB simple family (publication)

WO 9840377 A1 19980917; AU 5982198 A 19980929; EP 0968204 A1 20000105; HR P980116 A2 19990228; NO 994209 D0 19990831; NO 994209 L 19990831; ZA 981733 B 19980904

DOCDB simple family (application)

DK 9800058 W 19980216; AU 5982198 A 19980216; EP 98902960 A 19980216; HR P980116 A 19980306; NO 994209 A 19990831; ZA 981733 A 19980302