Global Patent Index - EP 0968209 A1

EP 0968209 A1 2000-01-05 - THIAZOLE BENZENESULFONAMIDES AS $g(b) 3? AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY

Title (en)

THIAZOLE BENZENESULFONAMIDES AS $g(b) 3? AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY

Title (de)

THIAZOLE BENZENESULFONAMIDE ALS BETA3-AGONISTEN ZUR BEHANDLUNG VON DIABETES UND FETTLEIBIGKEIT

Title (fr)

THIAZOLE BENZENESULFONAMIDES UTILISES COMME AGONISTES $g(b) 3? POUR LE TRAITEMENT DU DIABETE ET DE L'OBESITE

Publication

EP 0968209 A1 (EN)

Application

EP 98903677 A

Priority

  • GB 9705041 A
  • US 9801317 W
  • US 3676097 P

Abstract (en)

[origin: WO9832753A1] Thiazole substituted benzenesulfonamides are beta 3 adrenergic receptor agonists with very litte beta 1 and beta 2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduce neurogenic inflammation or as antidepressant agents. The compounds are prepared by coupling an aminoalkylphenyl-sulfonamide with an appropriately substituted epoxide. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for decreasing gut motility are also disclosed.

IPC 1-7 (main, further and additional classification)

C07D 417/12; A61K 31/44; A61K 31/47; C07D 417/14

IPC 8 full level (invention and additional information)

A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61P 1/00 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01)

CPC (invention and additional information)

C07D 417/12 (2013.01); C07D 417/14 (2013.01)

Citation (search report)

See references of WO 9832753A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9832753 A1 19980730; AR 011092 A1 20000802; AU 6038498 A 19980818; AU 728812 B2 20010118; BG 103686 A 20000630; BR 9807096 A 20000418; CA 2278739 A1 19980730; CN 1251099 A 20000419; EA 199900692 A1 20000228; EE 9900328 A 20000215; EP 0968209 A1 20000105; HR P980044 A2 19981031; HU 0002053 A2 20010828; HU 0002053 A3 20010928; ID 22273 A 19990923; IL 131130 D0 20010128; IS 5131 A 19990723; JP 2001509166 A 20010710; KR 20000070568 A 20001125; NO 993646 A 19990927; NO 993646 D0 19990727; PE 52299 A1 19990526; PL 334833 A1 20000327; SK 100099 A3 20000516; TR 9902442 T2 20000721

INPADOC legal status


2002-09-11 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020307

2001-10-10 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010827

2000-07-26 [RTI1] TITLE (CORRECTION)

- Free text: THIAZOLE BENZENESULFONAMIDES AS BETA 3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY

2000-01-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990830

2000-01-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-01-05 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: LT PAYMENT 19990830;LV PAYMENT 19990830;RO PAYMENT 19990830;SI PAYMENT 19990830