Global patent index - EP 0968302 A1

EP 0968302 A1 2000-01-05 - METHOD FOR PRODUCING ESTERS FREE OF ENANTIOMERS

Title (en)

METHOD FOR PRODUCING ESTERS FREE OF ENANTIOMERS

Title (de)

VERFAHREN ZUR HERSTELLUNG VON ENANTIOMERENREINEN ESTERN

Title (fr)

PRODUCTION D'ESTERS EXEMPTS D'ENANTIOMERES

Publication

EP 0968302 A1 (DE)

Application

EP 98910636 A

Priority

  • DE 19706337 A
  • EP 9800709 W

Abstract (en)

[origin: DE19706337A1] The invention relates to a method for producing enantiomer-free esters of formula (I) (Ia or Ib), where the substituents represent the following: R<1> is a hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl; R<2> and R<3> independently of each other are hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl-, C1-C6-alkylthio-, C1-C6-alkyl sulfinyl or C1-C6-alkyl sulfonyl-; R<4> is not equal to R<5> and independently of each other they are either hydrogen or an substituted or unsubstituted C1-C6-alkyl-, or together with the hydrogen atoms, to which they are bound, form a substituted or unsubstituted C3-C6-cyclo alkylidene; and R<6> is a substituted or unsubstituted aryl-, C1-C20-alkyl-, C3-C20-alkenyl-, C3-C20-alkynyl-, C1-C20-alkoxy-C1-C20-alkyl. The method is characterized in that racemic compounds of the formula (II), in which the substituents R<1> to R<5> have the meanings given above, are reacted with a lipase or esterase in the presence of vinyl esters of formula (III), where R<6> has the meaning given above and R<7> represents hydrogen or methyl, to form compounds of formula (I).

IPC 1-7 (main, further and additional classification)

C12P 41/00; C12P 17/18

IPC 8 full level (invention and additional information)

C07D 487/04 (2006.01); C12P 17/18 (2006.01); C12P 41/00 (2006.01)

CPC (invention and additional information)

C12P 41/004 (2013.01); C12P 17/182 (2013.01)

Citation (search report)

See references of WO 9837225A1

Designated contracting state (EPC)

CH DE DK FR GB IT LI NL

EPO simple patent family

DE 19706337 A1 19980820; CA 2274247 A1 19980827; CN 1127574 C 20031112; CN 1247572 A 20000315; EP 0968302 A1 20000105; JP 2001513628 A 20010904; US 6234811 B1 20010522; WO 9837225 A1 19980827

INPADOC legal status

2003-06-18 [18W] WITHDRAWN

- Effective date: 20030310

2000-01-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990331

2000-01-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): CH DE DK FR GB IT LI NL