EP 0969872 A2 20000112 - INDUCTION OF B CELL TOLERANCE
Title (en)
INDUCTION OF B CELL TOLERANCE
Title (de)
INDUKTION VON B-ZELLENTOLERANZ
Title (fr)
INDUCTION D'UNE TOLERANCE AUX CELLULES B
Publication
Application
Priority
- US 9802103 W 19980205
- US 79592597 A 19970205
Abstract (en)
[origin: WO9833528A2] The invention provides methods and compositions for promoting in a first species a state of tolerance against Gal alpha 1,3Gal epitopes present on a xenograft from a second species, thereby preventing hyperacute rejection (HAR) of the xenograft. The methods and compositions according to the invention cause the elimination or anergy of specific lymphoid according cells which are responsible for the production of xenoreactive natural antibodies (XNAs) which cause HAR of the xenograft. In a first aspect, the invention provides methods and tolerogenic compositions for inducing anergy in B cells which are specific for the Gal alpha 1,3Gal epitope. In a second aspect, the invention provides methods and tolerogenic compositions for inducing apoptosis in B cells specific for the Gal alpha 1,3Gal epitope.
IPC 1-7
IPC 8 full level
A61K 9/127 (2006.01); A61K 31/195 (2006.01); A61K 31/198 (2006.01); A61K 31/34 (2006.01); A61K 31/522 (2006.01); A61K 31/56 (2006.01); A61K 31/675 (2006.01); A61K 31/704 (2006.01); A61K 39/00 (2006.01); A61K 47/48 (2006.01); A61P 37/06 (2006.01)
CPC (source: EP)
A61K 9/1271 (2013.01); A61K 47/58 (2017.07); A61K 47/61 (2017.07); A61K 47/6825 (2017.07); A61K 47/6849 (2017.07); A61P 37/06 (2017.12)
Citation (search report)
See references of WO 9833528A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9833528 A2 19980806; WO 9833528 A3 19990211; WO 9833528 A9 20010614; AU 6319198 A 19980825; CA 2279544 A1 19980806; EP 0969872 A2 20000112; JP 2001518074 A 20011009
DOCDB simple family (application)
US 9802103 W 19980205; AU 6319198 A 19980205; CA 2279544 A 19980205; EP 98907366 A 19980205; JP 53321498 A 19980205