Global patent index - EP 0969872 A2

EP 0969872 A2 2000-01-12 - INDUCTION OF B CELL TOLERANCE

Title (en)

INDUCTION OF B CELL TOLERANCE

Title (de)

INDUKTION VON B-ZELLENTOLERANZ

Title (fr)

INDUCTION D'UNE TOLERANCE AUX CELLULES B

Publication

EP 0969872 A2 (EN)

Application

EP 98907366 A

Priority

  • US 9802103 W
  • US 79592597 A

Abstract (en)

[origin: WO9833528A2] The invention provides methods and compositions for promoting in a first species a state of tolerance against Gal alpha 1,3Gal epitopes present on a xenograft from a second species, thereby preventing hyperacute rejection (HAR) of the xenograft. The methods and compositions according to the invention cause the elimination or anergy of specific lymphoid according cells which are responsible for the production of xenoreactive natural antibodies (XNAs) which cause HAR of the xenograft. In a first aspect, the invention provides methods and tolerogenic compositions for inducing anergy in B cells which are specific for the Gal alpha 1,3Gal epitope. In a second aspect, the invention provides methods and tolerogenic compositions for inducing apoptosis in B cells specific for the Gal alpha 1,3Gal epitope.

IPC 1-7 (main, further and additional classification)

A61K 47/48

IPC 8 full level (invention and additional information)

A61K 39/00 (2006.01); A61K 9/127 (2006.01); A61K 31/195 (2006.01); A61K 31/198 (2006.01); A61K 31/34 (2006.01); A61K 31/522 (2006.01); A61K 31/56 (2006.01); A61K 31/675 (2006.01); A61K 31/704 (2006.01); A61K 47/48 (2006.01); A61P 37/06 (2006.01)

CPC (invention and additional information)

A61K 47/48561 (2013.01); A61K 9/1271 (2013.01); A61K 47/48176 (2013.01); A61K 47/4823 (2013.01); A61K 47/48469 (2013.01)

Citation (search report)

See references of WO 9833528A2

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9833528 A2 19980806; WO 9833528 A3 19990211; WO 9833528 A9 20010614; AU 6319198 A 19980825; CA 2279544 A1 19980806; EP 0969872 A2 20000112; JP 2001518074 A 20011009

INPADOC legal status

2003-05-14 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20021109

2000-05-31 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20000418

2000-01-12 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990712

2000-01-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE