Global patent index - EP 0970053 A1

EP 0970053 A1 2000-01-12 - 5-OXYSUBSTITUTED CHINOLINES AND THEIR USE AS CHOLESTEROL ESTER TRANSFER PROTEINS INHIBITORS

Title (en)

5-OXYSUBSTITUTED CHINOLINES AND THEIR USE AS CHOLESTEROL ESTER TRANSFER PROTEINS INHIBITORS

Title (de)

5-OXYSUBSTITUIERTE CHINOLINE UND IHRE VERWENDUNG ALS INHIBITOREN DES CHOLESTERIN-ESTER-TRANSFER-PROTEINS (CTEP)

Title (fr)

QUINOLINES A SUBSTITUTION OXY EN POSITION 5 ET LEUR UTILISATION COMME INHIBITEURS DE LA PROTEINE DE TRANSFERT D'ESTER DE CHOLESTEROL

Publication

EP 0970053 A1 (DE)

Application

EP 98912383 A

Priority

  • DE 19709125 A
  • EP 9801046 W

Abstract (en)

[origin: DE19709125A1] The invention relates to substituted chinolines of general formula (I) which are highly effective inhibitors of cholesterol ester transfer proteins (CTEP) and stimulate reverse cholesterol transfer. The inventive substances lower the LDL cholesterol level in the blood while at the same time increasing the HDL cholesterol level. Said substances can therefore be used in the treatment and prevention of hyperlipoproteinemia, hypolipoproteinimia, dyslipidiemia, hypertriglyceridemia, combined hyperlipidemia or arteriosclerosis.

IPC 1-7 (main, further and additional classification)

C07D 215/20; A61K 31/47; C07F 7/18

IPC 8 full level (invention and additional information)

A61K 31/47 (2006.01); A61P 3/06 (2006.01); A61P 9/10 (2006.01); A61P 43/00 (2006.01); C07D 215/20 (2006.01); C07D 215/48 (2006.01); C07F 7/18 (2006.01)

CPC (invention and additional information)

C07D 215/20 (2013.01); C07F 7/1856 (2013.01)

Citation (search report)

See references of WO 9839299A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

DE 19709125 A1 19980910; AU 6724598 A 19980922; EP 0970053 A1 20000112; JP 2001513790 A 20010904; WO 9839299 A1 19980911

INPADOC legal status

2002-07-17 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020108

2001-10-10 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010827

2000-01-12 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991006

2000-01-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE