EP 0970079 A1 20000112 - FARNESYL TRANSFERASE INHIBITING 1,8-ANNELATED QUINOLINONE DERIVATIVES SUBSTITUTED WITH N- OR C-LINKED IMIDAZOLES
Title (en)
FARNESYL TRANSFERASE INHIBITING 1,8-ANNELATED QUINOLINONE DERIVATIVES SUBSTITUTED WITH N- OR C-LINKED IMIDAZOLES
Title (de)
MIT DURCH N- ODER C-VERBUNDENEN IMIDAZOLE SUBSTITUIERTEN FARNESYL-TRANSFERASE INHIBITORENDEN 1,8-ANNELLIERTEN CHINOLON-DERIVATE
Title (fr)
DERIVES DE QUINOLINONE 1,8-ANNELEE SUBSTITUES PAR DES IMIZADOLES LIES EN N OU EN C INHIBANT LA TRANSEFRASE FARNESYLE
Publication
Application
Priority
- EP 98916890 A 19980303
- EP 97200708 A 19970310
- EP 97200709 A 19970310
- EP 9801296 W 19980303
Abstract (en)
[origin: WO9840383A1] This invention concerns compounds of formula (I), the pharmaceutically acceptable acid additions salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; -A- is a bivalent radical of formula; R<1> and R<2> each independently are hydrogen, hydroxy, halo, cyano, C1-6alkyl, trihalomethyl, trihalomethoxy, C2-6alkenyl, C1-6alkyloxy, hydroxyC1-6alkyloxy, C1-6alkyloxyC1-6alkyloxy, C1-6alkyloxycarbonyl, aminoC1-6alkyloxy, mono- or di(C1-6alkyl)aminoC1-6alkyloxy, Ar, Ar-C1-6alkyl, Ar-oxy, Ar-C1-6alkyloxy; or when on adjacent positions R<1> and R<2> taken together may form a bivalent radical; R<3> and R<4> each independently are hydrogen, halo, cyano, C1-6alkyl, C1-6alkyloxy, Ar-oxy, C1-6alkylthio, di(C1-6alkyl)amino, trihalomethyl, trihalomethoxy; or when on adjacent positions R<3> and R<4> taken together may form a bivalent radical; R<5> is an imidazolyl substituted with hydrogen or C1-6alkyl; R<6> hydrogen, hydroxy, halo, cyano, optionally substituted C1-6alkyl, C1-6alkyloxycarbonyl or Ar; or a radical of formula -O-R<7>, -S-R<8>, -N-R<8>R<9>; and Ar is optionally substituted phenyl; having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.
IPC 1-7
IPC 8 full level
A61K 31/47 (2006.01); A61K 31/4704 (2006.01); A61K 31/4709 (2006.01); A61K 31/4741 (2006.01); A61K 31/4745 (2006.01); A61K 31/5383 (2006.01); A61P 35/00 (2006.01); C07D 215/06 (2006.01); C07D 401/10 (2006.01); C07D 401/14 (2006.01); C07D 455/04 (2006.01); C07D 471/04 (2006.01); C07D 471/06 (2006.01); C07D 491/048 (2006.01); C07D 491/052 (2006.01); C07D 498/04 (2006.01); C07D 498/06 (2006.01)
CPC (source: EP KR US)
A61P 35/00 (2017.12 - EP); C07D 233/61 (2013.01 - KR); C07D 233/64 (2013.01 - KR); C07D 455/04 (2013.01 - EP KR US); C07D 471/06 (2013.01 - EP KR US)
Citation (search report)
See references of WO 9840383A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9840383 A1 19980917; AT 251159 T 20031015; AU 7031898 A 19980929; AU 748702 B2 20020613; BR 9808843 A 20000704; CA 2283587 A1 19980917; CA 2283587 C 20070501; CN 1128797 C 20031126; CN 1249753 A 20000405; DE 69818649 D1 20031106; DE 69818649 T2 20040701; EP 0970079 A1 20000112; EP 0970079 B1 20031001; ES 2209127 T3 20040616; HK 1024689 A1 20001020; HU 0001498 A2 20001128; HU 0001498 A3 20010129; IL 130362 A0 20000601; IL 130362 A 20040219; JP 2001515487 A 20010918; JP 4272262 B2 20090603; KR 100549096 B1 20060206; KR 20000069559 A 20001125; NO 313143 B1 20020819; NO 994268 D0 19990902; NO 994268 L 19991108; NZ 336234 A 20001027; PL 191564 B1 20060630; PL 335518 A1 20000425; RU 2204553 C2 20030520; SK 121799 A3 20000516; SK 283927 B6 20040504; TR 199902203 T2 19991221; TW 591030 B 20040611; US 2002049327 A1 20020425; US 6187786 B1 20010213; US 6444812 B1 20020903
DOCDB simple family (application)
EP 9801296 W 19980303; AT 98916890 T 19980303; AU 7031898 A 19980303; BR 9808843 A 19980303; CA 2283587 A 19980303; CN 98803064 A 19980303; DE 69818649 T 19980303; EP 98916890 A 19980303; ES 98916890 T 19980303; HK 00103861 A 20000627; HU 0001498 A 19980303; IL 13036298 A 19980303; JP 53919398 A 19980303; KR 19997005506 A 19990618; NO 994268 A 19990902; NZ 33623498 A 19980303; PL 33551898 A 19980303; RU 99121331 A 19980303; SK 121799 A 19980303; TR 9902203 T 19980303; TW 87102940 A 19980302; US 38085699 A 19991220; US 72539100 A 20001129