Global Patent Index - EP 0970079 A1

EP 0970079 A1 20000112 - FARNESYL TRANSFERASE INHIBITING 1,8-ANNELATED QUINOLINONE DERIVATIVES SUBSTITUTED WITH N- OR C-LINKED IMIDAZOLES

Title (en)

FARNESYL TRANSFERASE INHIBITING 1,8-ANNELATED QUINOLINONE DERIVATIVES SUBSTITUTED WITH N- OR C-LINKED IMIDAZOLES

Title (de)

MIT DURCH N- ODER C-VERBUNDENEN IMIDAZOLE SUBSTITUIERTEN FARNESYL-TRANSFERASE INHIBITORENDEN 1,8-ANNELLIERTEN CHINOLON-DERIVATE

Title (fr)

DERIVES DE QUINOLINONE 1,8-ANNELEE SUBSTITUES PAR DES IMIZADOLES LIES EN N OU EN C INHIBANT LA TRANSEFRASE FARNESYLE

Publication

EP 0970079 A1 20000112 (EN)

Application

EP 98916890 A 19980303

Priority

  • EP 98916890 A 19980303
  • EP 97200708 A 19970310
  • EP 97200709 A 19970310
  • EP 9801296 W 19980303

Abstract (en)

[origin: WO9840383A1] This invention concerns compounds of formula (I), the pharmaceutically acceptable acid additions salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; -A- is a bivalent radical of formula; R<1> and R<2> each independently are hydrogen, hydroxy, halo, cyano, C1-6alkyl, trihalomethyl, trihalomethoxy, C2-6alkenyl, C1-6alkyloxy, hydroxyC1-6alkyloxy, C1-6alkyloxyC1-6alkyloxy, C1-6alkyloxycarbonyl, aminoC1-6alkyloxy, mono- or di(C1-6alkyl)aminoC1-6alkyloxy, Ar, Ar-C1-6alkyl, Ar-oxy, Ar-C1-6alkyloxy; or when on adjacent positions R<1> and R<2> taken together may form a bivalent radical; R<3> and R<4> each independently are hydrogen, halo, cyano, C1-6alkyl, C1-6alkyloxy, Ar-oxy, C1-6alkylthio, di(C1-6alkyl)amino, trihalomethyl, trihalomethoxy; or when on adjacent positions R<3> and R<4> taken together may form a bivalent radical; R<5> is an imidazolyl substituted with hydrogen or C1-6alkyl; R<6> hydrogen, hydroxy, halo, cyano, optionally substituted C1-6alkyl, C1-6alkyloxycarbonyl or Ar; or a radical of formula -O-R<7>, -S-R<8>, -N-R<8>R<9>; and Ar is optionally substituted phenyl; having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.

IPC 1-7

C07D 471/06; C07D 498/06; A61K 31/47

IPC 8 full level

C07D 215/06 (2006.01); A61K 31/47 (2006.01); A61K 31/4704 (2006.01); A61K 31/4709 (2006.01); A61K 31/4741 (2006.01); A61K 31/4745 (2006.01); A61K 31/5383 (2006.01); A61P 35/00 (2006.01); C07D 401/10 (2006.01); C07D 401/14 (2006.01); C07D 455/04 (2006.01); C07D 471/04 (2006.01); C07D 471/06 (2006.01); C07D 491/048 (2006.01); C07D 491/052 (2006.01); C07D 498/04 (2006.01); C07D 498/06 (2006.01)

CPC (source: EP KR)

A61P 35/00 (2018.01 - EP); C07D 233/61 (2013.01 - KR); C07D 233/64 (2013.01 - KR); C07D 455/04 (2013.01 - EP KR); C07D 471/06 (2013.01 - EP KR)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9840383 A1 19980917; AT 251159 T 20031015; AU 7031898 A 19980929; AU 748702 B2 20020613; BR 9808843 A 20000704; CA 2283587 A1 19980917; CA 2283587 C 20070501; CN 1128797 C 20031126; CN 1249753 A 20000405; DE 69818649 D1 20031106; DE 69818649 T2 20040701; EP 0970079 A1 20000112; EP 0970079 B1 20031001; ES 2209127 T3 20040616; HK 1024689 A1 20001020; HU 0001498 A2 20001128; HU 0001498 A3 20010129; IL 130362 A 20040219; IL 130362 D0 20000601; JP 2001515487 A 20010918; JP 4272262 B2 20090603; KR 100549096 B1 20060206; KR 20000069559 A 20001125; NO 313143 B1 20020819; NO 994268 D0 19990902; NO 994268 L 19991108; NZ 336234 A 20001027; PL 191564 B1 20060630; PL 335518 A1 20000425; RU 2204553 C2 20030520; SK 121799 A3 20000516; SK 283927 B6 20040504; TR 199902203 T2 19991221; TW 591030 B 20040611; US 2002049327 A1 20020425; US 6187786 B1 20010213; US 6444812 B1 20020903

DOCDB simple family (application)

EP 9801296 W 19980303; AT 98916890 T 19980303; AU 7031898 A 19980303; BR 9808843 A 19980303; CA 2283587 A 19980303; CN 98803064 A 19980303; DE 69818649 T 19980303; EP 98916890 A 19980303; ES 98916890 T 19980303; HK 00103861 A 20000627; HU 0001498 A 19980303; IL 13036298 A 19980303; JP 53919398 A 19980303; KR 19997005506 A 19990618; NO 994268 A 19990902; NZ 33623498 A 19980303; PL 33551898 A 19980303; RU 99121331 A 19980303; SK 121799 A 19980303; TR 9902203 T 19980303; TW 87102940 A 19980302; US 38085699 A 19991220; US 72539100 A 20001129