EP 0970201 A1 20000112 - RETROVIRAL VECTORS CAPABLE OF TRANSDUCING NON-DIVIDING CELLS
Title (en)
RETROVIRAL VECTORS CAPABLE OF TRANSDUCING NON-DIVIDING CELLS
Title (de)
RETROVIRALE VEKTOREN, DIE SICH NICHT TEILENDE ZELLEN TRANSDUZIEREN KÖNNEN
Title (fr)
VECTEURS RETROVIRAUX POUVANT TRANSDUIRE DES CELLULES NE SE DIVISANT PAS
Publication
Application
Priority
- US 9715934 W 19970908
- US 71531896 A 19960917
Abstract (en)
[origin: WO9812314A1] In accordance with the present invention, methods have been developed to modify retroviral vectors derived from viruses which are not known to be pathogenic in humans (e.g., MLV), so that such vectors are rendered capable of transducing heterologous sequences into non-dividing cells. Thus, it has been discovered that retroviruses can be rendered capable of infecting non-dividing cells by introducing into the viral particle one of several specifically defined modifications. For example, an element which is recognized by the nuclear import machinery of a non-dividing cell can be associated with the nucleoprotein complex of the retrovirus. Alternatively, at least one protein encoded by viral gag or pol nucleic acid is modified so as to be recognized by the nuclear import machinery of a non-dividing cell.
IPC 1-7
IPC 8 full level
C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 15/09 (2006.01); C12N 15/867 (2006.01)
CPC (source: EP)
C12N 15/86 (2013.01); C12N 2740/13043 (2013.01); C12N 2740/13045 (2013.01); C12N 2740/13052 (2013.01); C12N 2740/16022 (2013.01); C12N 2810/6054 (2013.01)
Citation (search report)
See references of WO 9812314A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE
DOCDB simple family (publication)
WO 9812314 A1 19980326; AU 4261797 A 19980414; CA 2265522 A1 19980326; EP 0970201 A1 20000112; JP 2001501815 A 20010213
DOCDB simple family (application)
US 9715934 W 19970908; AU 4261797 A 19970908; CA 2265522 A 19970908; EP 97940952 A 19970908; JP 51472598 A 19970908