Global patent index - EP 0970201 A1

EP 0970201 A1 2000-01-12 - RETROVIRAL VECTORS CAPABLE OF TRANSDUCING NON-DIVIDING CELLS

Title (en)

RETROVIRAL VECTORS CAPABLE OF TRANSDUCING NON-DIVIDING CELLS

Title (de)

RETROVIRALE VEKTOREN, DIE SICH NICHT TEILENDE ZELLEN TRANSDUZIEREN KÖNNEN

Title (fr)

VECTEURS RETROVIRAUX POUVANT TRANSDUIRE DES CELLULES NE SE DIVISANT PAS

Publication

EP 0970201 A1 (EN)

Application

EP 97940952 A

Priority

  • US 9715934 W
  • US 71531896 A

Abstract (en)

[origin: WO9812314A1] In accordance with the present invention, methods have been developed to modify retroviral vectors derived from viruses which are not known to be pathogenic in humans (e.g., MLV), so that such vectors are rendered capable of transducing heterologous sequences into non-dividing cells. Thus, it has been discovered that retroviruses can be rendered capable of infecting non-dividing cells by introducing into the viral particle one of several specifically defined modifications. For example, an element which is recognized by the nuclear import machinery of a non-dividing cell can be associated with the nucleoprotein complex of the retrovirus. Alternatively, at least one protein encoded by viral gag or pol nucleic acid is modified so as to be recognized by the nuclear import machinery of a non-dividing cell.

IPC 1-7 (main, further and additional classification)

C12N 15/09; C12N 7/01; C12N 7/02

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 15/867 (2006.01)

CPC (invention and additional information)

C12N 15/86 (2013.01); C12N 2740/13043 (2013.01); C12N 2740/13045 (2013.01); C12N 2740/13052 (2013.01); C12N 2740/16022 (2013.01); C12N 2810/6054 (2013.01)

Citation (search report)

See references of WO 9812314A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

EPO simple patent family

WO 9812314 A1 19980326; AU 4261797 A 19980414; CA 2265522 A1 19980326; EP 0970201 A1 20000112; JP 2001501815 A 20010213

INPADOC legal status

2000-08-09 [18W] WITHDRAWN

- Date of withdrawal: 20000615

2000-01-12 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990408

2000-01-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE