Global Patent Index - EP 0970216 A1

EP 0970216 A1 2000-01-12 - TRANSGENIC MICE EXPRESSING THE $i(H/K-RAS 4B) CHIMERIC GENE

Title (en)

TRANSGENIC MICE EXPRESSING THE $i(H/K-RAS 4B) CHIMERIC GENE

Title (de)

TRANSGENE MÄUSE, DIE DAS CHIMÄRE GEN H/K-RAS-4B EXPRIMIEREN.

Title (fr)

SOURIS TRANSGENIQUES EXPRIMANT LE GENE CHIMERE $i(H/K-RAS 4B)

Publication

EP 0970216 A1 (EN)

Application

EP 98959249 A

Priority

  • KR 9800396 W
  • KR 19970066474 A

Abstract (en)

[origin: WO9929846A1] The present invention relates to the transgenic mouse expressing the H/K-ras 4B chimeric gene to form a mammary tumor. Particularly, the present invention relates to the expression vector producing H/K-Ras 4B chimeric protein by using MMTV (mouse mammary tumor virus) promoter. This protein contains the first 164 amino acids of the H-Ras followed by the last 24 amino acids of K-Ras 4B. The second, it relates to the transgenic mouse expressing the H/K-Ras 4B protein with a mammary tumor, and the third, the method of preparation thereof. And the transgenic mouse of the present invention can be used a useful tool not only to research a function of ras-oncogene but also to screen in vivo efficacy anti-cancer drug, especially which targeted ras-blocker.

IPC 1-7 (main, further and additional classification)

C12N 15/12; C12N 1/21

IPC 8 full level (invention and additional information)

A01K 67/027 (2006.01); A01K 67/00 (2006.01); C07K 14/82 (2006.01); C12N 1/21 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12N 15/85 (2006.01); C12R 1/19 (2006.01)

CPC (invention and additional information)

C12N 15/8509 (2013.01); A01K 67/0275 (2013.01); A01K 67/0278 (2013.01); C07K 14/82 (2013.01); A01K 2207/15 (2013.01); A01K 2217/00 (2013.01); A01K 2217/05 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0331 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

See references of WO 9929846A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9929846 A1 19990617; EP 0970216 A1 20000112; JP 2000513590 A 20001017; KR 100367208 B1 20021223

INPADOC legal status


2004-11-17 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040511

2003-07-23 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030611

2000-01-12 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990728

2000-01-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE