Global Patent Index - EP 0970216 A1

EP 0970216 A1 2000-01-12 - TRANSGENIC MICE EXPRESSING THE $i(H/K-RAS 4B) CHIMERIC GENE

Title (en)

TRANSGENIC MICE EXPRESSING THE $i(H/K-RAS 4B) CHIMERIC GENE

Title (de)

TRANSGENE MÄUSE, DIE DAS CHIMÄRE GEN H/K-RAS-4B EXPRIMIEREN.

Title (fr)

SOURIS TRANSGENIQUES EXPRIMANT LE GENE CHIMERE $i(H/K-RAS 4B)

Publication

EP 0970216 A1 (EN)

Application

EP 98959249 A

Priority

  • KR 9800396 W
  • KR 19970066474 A

Abstract (en)

[origin: WO9929846A1] The present invention relates to the transgenic mouse expressing the H/K-ras 4B chimeric gene to form a mammary tumor. Particularly, the present invention relates to the expression vector producing H/K-Ras 4B chimeric protein by using MMTV (mouse mammary tumor virus) promoter. This protein contains the first 164 amino acids of the H-Ras followed by the last 24 amino acids of K-Ras 4B. The second, it relates to the transgenic mouse expressing the H/K-Ras 4B protein with a mammary tumor, and the third, the method of preparation thereof. And the transgenic mouse of the present invention can be used a useful tool not only to research a function of ras-oncogene but also to screen in vivo efficacy anti-cancer drug, especially which targeted ras-blocker.

IPC 1-7

C12N 15/12; C12N 1/21

IPC 8 full level

A01K 67/027 (2006.01); A01K 67/00 (2006.01); C07K 14/82 (2006.01); C12N 1/21 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12N 15/85 (2006.01); C12R 1/19 (2006.01)

CPC

A01K 67/0275 (2013.01); A01K 67/0278 (2013.01); C12N 15/8509 (2013.01); C07K 14/82 (2013.01); A01K 2207/15 (2013.01); A01K 2217/00 (2013.01); A01K 2217/05 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0331 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

See references of WO 9929846A1

DCS

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family

WO 9929846 A1 19990617; EP 0970216 A1 20000112; JP 2000513590 A 20001017; KR 100367208 B1 20021223; KR 19990047906 A 19990705