Global Patent Index - EP 0970241 A1

EP 0970241 A1 20000112 - (IN VITRO) EVOLUTION OF OLIGONUCLEOTIDES

Title (en)

(IN VITRO) EVOLUTION OF OLIGONUCLEOTIDES

Title (de)

IN VITRO EVOLUTION VON OLIGONUKLEOTIDEN

Title (fr)

EVOLUTION IN VITRO D'OLIGONUCLEOTIDES

Publication

EP 0970241 A1 20000112 (EN)

Application

EP 97935737 A 19970826

Priority

  • IL 9700283 W 19970826
  • IL 12046697 A 19970317

Abstract (en)

[origin: WO9841654A1] The present invention concerns a method for in vitro evolution of oligonucleotides. In the method of the invention the negative selection step, in which undesired oligonucleotides are removed, utilizes a unique random tag sequence attached to the evolving oligonucleotides which enables to eliminate, by hybridization, undesired oligonucleotides.

IPC 1-7

C12Q 1/68

IPC 8 full level

C12N 15/09 (2006.01); C12N 15/10 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2006.01)

CPC (source: EP)

C12N 15/1048 (2013.01); C12N 15/1058 (2013.01); C12N 15/1072 (2013.01); C12N 15/113 (2013.01); C07K 2319/00 (2013.01); C12N 2310/124 (2013.01); C12Q 1/6811 (2013.01)

Citation (search report)

See references of WO 9841654A1

Designated contracting state (EPC)

CH DE ES FR GB IT LI

DOCDB simple family (publication)

WO 9841654 A1 19980924; AU 3862197 A 19981012; EP 0970241 A1 20000112; IL 120466 D0 19970713; JP 2001515358 A 20010918

DOCDB simple family (application)

IL 9700283 W 19970826; AU 3862197 A 19970826; EP 97935737 A 19970826; IL 12046697 A 19970317; JP 54028898 A 19970826