EP 0971916 A1 20000119 - N-(ARGINYL)BENZENESULPHONAMIDE DERIVATIVES AND USE THEREOF AS ANTITHROMBOTIC AGENTS
Title (en)
N-(ARGINYL)BENZENESULPHONAMIDE DERIVATIVES AND USE THEREOF AS ANTITHROMBOTIC AGENTS
Title (de)
N-(ARGINYL)BENZENSULFONAMIDDERIVATE UND IHRE VERWENDUNG ALS ANTITHROMBOTISCHE MITTEL
Title (fr)
DERIVES DE N-(ARGINYL)BENZENESULFONAMIDE ET LEUR UTILISATION COMME AGENTS ANTITHROMBOTIQUES
Publication
Application
Priority
- FR 9800532 W 19980317
- FR 9703392 A 19970320
Abstract (en)
[origin: FR2761065A1] The invention concerns compounds of formula (I) in which: R, R1 and R'1 each represent hydrogen, (C1-C4) alkyl, (C1-C4) alkoxycarbonyl, (C2-C4) alkenyloxycarbonyl, phenyl (C1-C4) alkoxycarbonyl, (C1-C4) alkanoyl, phenyl (C1-C4) alkanoyl, phenyl (C1-C4) alkyl (C1-C4) alkanoyl; R2 represents piperidin-1-yl, spiro[(C3-C6) cycloalkane-1,4'-piperidin]-1-yl, 1,2,3,6-tetrahydropyridin, hexahydro-1H-azepin-1-yl, heptahydroazocin-1-yl, octahydro-1H-azonin-1-yl (a) (A' -B being -CONR", R" = H or (C1-C4) alkyl; m and p = 1 or 2; (b) (Q = C or N, D being (C1-C4) alkyl or -CH2CF3, r = 1 to 3); R3 represents hydrogen, (C1-C5) alkyl, linear or branched; -COR5 [R5 is (C1-C4) alkyl, -(CH2)nOCH3, -CH2O(C2H4O)nCH3, -(CH2)nCF3, -(CH2)n OH (n = 1 to 4)], SO2R6, -CONHR6, -SO2N(R6)2 [R6 = (C1-C4) alkyl]; R4 represents H or halogen, A represents halogen, phenyl, a heterocyclic compound, cyclo(C5-C8) alkyl. The compounds have therapeutic uses as antithrombotic agents.
IPC 1-7
C07D 409/12; C07D 295/185; C07D 401/12; C07D 213/40; C07D 333/20; C07D 211/18; C07D 211/70; A61K 31/435
IPC 8 full level
C07C 311/46 (2006.01); C07D 211/18 (2006.01); C07D 211/70 (2006.01); C07D 213/40 (2006.01); C07D 295/185 (2006.01); C07D 333/20 (2006.01); C07D 401/12 (2006.01); C07D 409/12 (2006.01)
CPC (source: EP)
C07C 311/46 (2013.01); C07D 211/18 (2013.01); C07D 211/70 (2013.01); C07D 213/40 (2013.01); C07D 295/185 (2013.01); C07D 333/20 (2013.01); C07D 401/12 (2013.01); C07D 409/12 (2013.01)
Citation (search report)
See references of WO 9842700A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
FR 2761065 A1 19980925; FR 2761065 B1 20000303; AR 012096 A1 20000927; AU 6924398 A 19981020; EP 0971916 A1 20000119; WO 9842700 A1 19981001; ZA 982355 B 19980922
DOCDB simple family (application)
FR 9703392 A 19970320; AR P980101211 A 19980318; AU 6924398 A 19980317; EP 98914932 A 19980317; FR 9800532 W 19980317; ZA 982355 A 19980319