Global Patent Index - EP 0971916 A1

EP 0971916 A1 2000-01-19 - N-(ARGINYL)BENZENESULPHONAMIDE DERIVATIVES AND USE THEREOF AS ANTITHROMBOTIC AGENTS

Title (en)

N-(ARGINYL)BENZENESULPHONAMIDE DERIVATIVES AND USE THEREOF AS ANTITHROMBOTIC AGENTS

Title (de)

N-(ARGINYL)BENZENSULFONAMIDDERIVATE UND IHRE VERWENDUNG ALS ANTITHROMBOTISCHE MITTEL

Title (fr)

DERIVES DE N-(ARGINYL)BENZENESULFONAMIDE ET LEUR UTILISATION COMME AGENTS ANTITHROMBOTIQUES

Publication

EP 0971916 A1 (FR)

Application

EP 98914932 A

Priority

  • FR 9800532 W
  • FR 9703392 A

Abstract (en)

[origin: FR2761065A1] The invention concerns compounds of formula (I) in which: R, R1 and R'1 each represent hydrogen, (C1-C4) alkyl, (C1-C4) alkoxycarbonyl, (C2-C4) alkenyloxycarbonyl, phenyl (C1-C4) alkoxycarbonyl, (C1-C4) alkanoyl, phenyl (C1-C4) alkanoyl, phenyl (C1-C4) alkyl (C1-C4) alkanoyl; R2 represents piperidin-1-yl, spiro[(C3-C6) cycloalkane-1,4'-piperidin]-1-yl, 1,2,3,6-tetrahydropyridin, hexahydro-1H-azepin-1-yl, heptahydroazocin-1-yl, octahydro-1H-azonin-1-yl (a) (A' -B being -CONR", R" = H or (C1-C4) alkyl; m and p = 1 or 2; (b) (Q = C or N, D being (C1-C4) alkyl or -CH2CF3, r = 1 to 3); R3 represents hydrogen, (C1-C5) alkyl, linear or branched; -COR5 [R5 is (C1-C4) alkyl, -(CH2)nOCH3, -CH2O(C2H4O)nCH3, -(CH2)nCF3, -(CH2)n OH (n = 1 to 4)], SO2R6, -CONHR6, -SO2N(R6)2 [R6 = (C1-C4) alkyl]; R4 represents H or halogen, A represents halogen, phenyl, a heterocyclic compound, cyclo(C5-C8) alkyl. The compounds have therapeutic uses as antithrombotic agents.

IPC 1-7

C07D 409/12; A61K 31/435; C07D 211/18; C07D 211/70; C07D 213/40; C07D 295/185; C07D 333/20; C07D 401/12

IPC 8 full level

C07C 311/46 (2006.01); C07D 211/18 (2006.01); C07D 211/70 (2006.01); C07D 213/40 (2006.01); C07D 295/185 (2006.01); C07D 333/20 (2006.01); C07D 401/12 (2006.01); C07D 409/12 (2006.01)

CPC

C07D 213/40 (2013.01); C07C 311/46 (2013.01); C07D 211/18 (2013.01); C07D 211/70 (2013.01); C07D 295/185 (2013.01); C07D 333/20 (2013.01); C07D 401/12 (2013.01); C07D 409/12 (2013.01)

Citation (search report)

See references of WO 9842700A1

DCS

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family

FR 2761065 A1 19980925; FR 2761065 B1 20000303; AR 012096 A1 20000927; AU 6924398 A 19981020; EP 0971916 A1 20000119; WO 9842700 A1 19981001; ZA 9802355 B 19980922