Global Patent Index - EP 0971928 A1

EP 0971928 A1 20000119 - QUINOLINE-2(1H)-ONE AND DIHYDROQUINOLINE-2(1H)-ONE DERIVATIVES AS LIGANDS OF 5-HT, 5-HT2 AND 5-HT1-LIKE RECEPTORS

Title (en)

QUINOLINE-2(1H)-ONE AND DIHYDROQUINOLINE-2(1H)-ONE DERIVATIVES AS LIGANDS OF 5-HT, 5-HT2 AND 5-HT1-LIKE RECEPTORS

Title (de)

CHINOLIN-2-ON- UND DIHYDROCHINOLIN-2-ON-DERIVATE ALS LIGANDEN DES REZEPTOREN 5-HT,5-HT2 UND 5-HT1-LIKE

Title (fr)

DERIVES DE QUINOLEIN-2(1H)-ONE ET DE DIHYDROQUINOLEIN-2(1H)-ONE EN TANT QUE LINGANDS DES RECEPTEURS 5-HT, 5-HT2 ET 5-HT1-LIKE

Publication

EP 0971928 A1 20000119 (FR)

Application

EP 98914928 A 19980317

Priority

  • FR 9800528 W 19980317
  • FR 9703387 A 19970320

Abstract (en)

[origin: FR2761071A1] The invention concerns compounds of formula (I) in which <o>---</o> represents a single or double bond; G represents (G) in position 3 or 4; m = 2 to 4; Z represents a nitrogen atom or a -CH- group; R1 and R2 each represent independently of each other, a hydrogen or halogen atom, an amino, hydroxy, nitro, cyano, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl, trifluoromethoxy, -COOH, -COOR4, -CONH2, -CONHR4, -CONR4R5, -SR4, -SO2R4, -NHCOR4, -NHSO2R4, -N(R4)2 group; R3 represents a hydrogen atom, a (C1-C4) alkyl, -(CH2)pOH, -(CH2)pNH2, -(CH2)nCOOH, -(CH2)nCOOR4, -(CH2)nCN, -(CH2)n-tetrazolyl, -(CH2)nCONH2, -(CH2)nCONHOH, -(CH2)pSH, (CH2)nSO3H, -(CH2)nSO2NH2, -(CH2)nSO2NHR4, -(CH2)nSO2NR4R5, -(CH2)nCONHR4, -(CH2)nCONR4R5, -(CH2)pNHSO2R4, -(CH2)pNHCOR4, -(CH2)pOCOR4 group; R4 and R5 are each a (C1-C4) alkyl group; n = 1 to 4; p = 2 to 4; and A represents a benzo group optionally substituted or not. The invention is applicable in therapeutics.

IPC 1-7

C07D 491/04; A61K 31/47; C07D 401/12; C07D 471/04; C07D 513/04; C07F 9/12

IPC 8 full level

C07D 401/12 (2006.01); C07D 471/04 (2006.01); C07D 491/04 (2006.01); C07D 491/048 (2006.01); C07D 513/04 (2006.01)

CPC (source: EP)

C07D 401/12 (2013.01); C07D 471/04 (2013.01); C07D 491/04 (2013.01); C07D 513/04 (2013.01)

Citation (search report)

See references of WO 9842712A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

FR 2761071 A1 19980925; FR 2761071 B1 19991203; AR 012094 A1 20000927; AU 6923998 A 19981020; EP 0971928 A1 20000119; WO 9842712 A1 19981001; ZA 982362 B 19980923

DOCDB simple family (application)

FR 9703387 A 19970320; AR P980101209 A 19980318; AU 6923998 A 19980317; EP 98914928 A 19980317; FR 9800528 W 19980317; ZA 982362 A 19980319