Global patent index - EP 0971929 A1

EP 0971929 A1 2000-01-19 - 2,3-DIHYDROFURO 3,2-(b) PYRIDIN, PREPARATION AND APPLICATION THEREOF IN THERAPY

Title (en)

2,3-DIHYDROFURO 3,2-(b) PYRIDIN, PREPARATION AND APPLICATION THEREOF IN THERAPY

Title (de)

2,3-DIHYDROFURO¬3,2-B PYRIDINDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND THERAPEUTISCHE VERWENDUNG

Title (fr)

DERIVES DE 2,3-DIHYDROFURO 3,2-(b) PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publication

EP 0971929 A1 (FR)

Application

EP 98914931 A

Priority

  • FR 9800531 W
  • FR 9703395 A

Abstract (en)

[origin: FR2761072A1] The invention concerns compounds of general formula (I) in which R1 represents a hydrogen atom, a (C1-C6)alkyl group or a phenyl(C1-C4)alkyl group; R2 represents a hydrogen atom of a (C1-C6)alkyl group; and R3, R4 and R5 represent each, independently of one another, a hydrogen or halogen atom or a trifluoromethyl, cyano, hydroxy, (C1-C6)alkyl or (C1-C6)alkoxy group. The results of biological assays carried out on said compounds show that they are powerful and selective cholinergic ligands for nicotinic receptors. These results suggest that the compounds can be used for treating or preventing disorders related to the dysfunction of nicotinic receptors, in particular in the central nervous system or the gastro-intestinal system.

IPC 1-7 (main, further and additional classification)

C07D 491/048; A61K 31/435

IPC 8 full level (invention and additional information)

A61K 31/4355 (2006.01); A61P 1/00 (2006.01); A61P 25/00 (2006.01); A61P 43/00 (2006.01); C07D 491/04 (2006.01); C07D 491/048 (2006.01)

CPC (invention and additional information)

C07D 491/04 (2013.01)

Citation (search report)

See references of WO 9842713A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

FR 2761072 A1 19980925; FR 2761072 B1 19990423; AR 012097 A1 20000927; AU 6924298 A 19981020; BG 103684 A 20000630; BR 9808346 A 20000523; CA 2282320 A1 19981001; CN 1251105 A 20000419; CO 4940417 A1 20000724; EE 9900414 A 20000417; EP 0971929 A1 20000119; HU 0002335 A2 20010528; HU 0002335 A3 20020729; IL 131254 D0 20010128; JP 2001518099 A 20011009; KR 20000076282 A 20001226; NO 994527 A 19991118; NO 994527 D0 19990917; NZ 337566 A 20000929; PL 335759 A1 20000522; SK 127699 A3 20000516; TR 9902115 T2 20000121; US 6143761 A 20001107; WO 9842713 A1 19981001; ZA 9802365 B 19980923

INPADOC legal status

2007-11-14 [RTI1] TITLE (CORRECTION)

- Free Format Text: 2,3-DIHYDROFURO 3,2-(B) PYRIDIN, PREPARATION AND APPLICATION THEREOF IN THERAPY

2003-04-16 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20021001

2000-07-26 [RTI1] TITLE (CORRECTION)

- Free Format Text: 2,3-DIHYDROFURO 3,2-(B))PYRIDIN, PREPARATION AND APPLICATION THEREOF IN THERAPY

2000-01-19 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991020

2000-01-19 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE