EP 0971944 A1 20000119 - ANTI-VIRAL GUANOSINE-RICH TETRAD FORMING OLIGONUCLEOTIDES
Title (en)
ANTI-VIRAL GUANOSINE-RICH TETRAD FORMING OLIGONUCLEOTIDES
Title (de)
ANTIVIRALE, GUANOSIN-REICHE OLIGONUKLEOTIDE, DIE EINE TETRADE BILDEN
Title (fr)
OLIGONUCLEOTIDES ANTIVIRAUX RICHES EN GUANOSINE FORMANT DES TETRADES
Publication
Application
Priority
- US 9801974 W 19980203
- US 3737497 P 19970204
- US 98757497 A 19971209
Abstract (en)
[origin: WO9833807A1] Guanosine-rich oligonucleotides having sequences that favor the formation under physiological conditions of a stable four-stranded structure containing two stacked guanosine quartets (G4s) are disclosed. These oligonucleotides demonstrate enhanced nuclease resistance, cellular uptake and biological efficacy. Methods and composition for treating viral infection using these guanosine-rich oligonucleotides are also disclosed. Certain embodiments of the new oligonucleotides are 16-17 nucleotides long and contain at least one C-5 propynyl dU substitution. A method for designing anti-viral oligonucleotides is also disclosed.
IPC 1-7
IPC 8 full level
C07H 21/00 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07H 21/00 (2013.01); C12N 15/1132 (2013.01); A61K 38/00 (2013.01); C12N 2310/151 (2013.01); C12N 2310/18 (2013.01); C12N 2310/315 (2013.01); C12N 2310/335 (2013.01)
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
WO 9833807 A1 19980806; AU 6262598 A 19980825; CA 2279488 A1 19980806; EP 0971944 A1 20000119; EP 0971944 A4 20050126
DOCDB simple family (application)
US 9801974 W 19980203; AU 6262598 A 19980203; CA 2279488 A 19980203; EP 98904843 A 19980203