Title (en)

DIAGNOSIS METHOD AND REAGENTS

Title (de)

DIAGNOSEVERFAHREN UND REAGENZIEN

Title (fr)

REACTIFS POUR DIAGNOSTICS ET PROCEDE CORRESPONDANT

Publication

EP 0971952 A2 20000119 (EN)

Application

EP 98917502 A 19980402

Priority

• IB 9800705 W 19980402
• US 4316397 P 19970410

Abstract (en)

[origin: WO9845322A2] The invention relates to methods and reagents for the diagnosis and treatment of a disease caused by or associated with an RNA molecule having a transcript mutation giving rise to a frameshift mutation. The diagnostic methods include the steps of providing a body fluid or tissue sample from a patient; and analyzing the sample for the presence of an RNA molecule having a frameshift mutation or a protein encoded thereby, wherein the presence of the mutated RNA molecule or encoded protein is indicative of the disease. The therapeutic treatments include administering substances which selectively eliminate mutate RNA molecule from the cell.

IPC 1-7

C07K 14/00; C12Q 1/68; G01N 33/53; C12N 15/85; A61K 48/00

IPC 8 full level

A61K 9/127 (2006.01); A61K 31/7105 (2006.01); A61K 31/711 (2006.01); A61K 35/28 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01); A61P 3/10 (2006.01); A61P 21/04 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 35/00 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6827 (2018.01); C12Q 1/6858 (2018.01); C12Q 1/6883 (2018.01); G01N 33/68 (2006.01)

CPC (source: EP)

A61P 3/10 (2017.12); A61P 21/04 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/28 (2017.12); A61P 35/00 (2017.12); C12Q 1/6827 (2013.01); C12Q 1/6858 (2013.01); C12Q 1/6883 (2013.01); G01N 33/6893 (2013.01); G01N 33/6896 (2013.01); C12Q 2600/156 (2013.01)

Citation (search report)

See references of WO 9845322A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9845322 A2 19981015; WO 9845322 A3 19990415; AU 7071598 A 19981030; CA 2287084 A1 19981015; EP 0971952 A2 20000119; JP 2001522241 A 20011113

DOCDB simple family (application)

IB 9800705 W 19980402; AU 7071598 A 19980402; CA 2287084 A 19980402; EP 98917502 A 19980402; JP 54254598 A 19980402