Global Patent Index - EP 0972074 A1

EP 0972074 A1 2000-01-19 - A METHOD FOR IDENTIFYING THE SITE OF ACTION OF XENOBIOTIC CHEMICALS

Title (en)

A METHOD FOR IDENTIFYING THE SITE OF ACTION OF XENOBIOTIC CHEMICALS

Title (de)

EINE METHODE ZUR IDENTIFIZIERUNG DER WIRKUNGSSTELLEN XENOBIOTISCHER CHEMIKALIEN

Title (fr)

PROCEDE POUR IDENTIFIER LE SITE D'ACTION D'AGENTS CHIMIQUES XENOBIOTIQUES

Publication

EP 0972074 A1 (EN)

Application

EP 98907633 A

Priority

  • US 9803684 W
  • US 3958297 P

Abstract (en)

[origin: WO9838336A1] A method is disclosed for the discovery of the site of action of xenobiotic compounds. The method involves subjecting a detector cell comprising a genotoxic-sensitive promoter operably linked to a luminescent reporter gene complex. Exposure of the detector bacteria to compounds that are genotoxic results in an increase in luminescence. Such compounds are grouped and may be analyzed for pharmaceutical activity. Exposure of the detector bacteria to active xenobiotics that are not genotoxic results in inhibition of bioluminescence or stable luminescence. Subjection of the detector bacteria to a screen such as nutritional reversal or genetic titration reveals the site of action of the compound.

IPC 1-7 (main, further and additional classification)

C12Q 1/68

IPC 8 full level (invention and additional information)

G01N 33/50 (2006.01); C12N 1/21 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01)

CPC (invention and additional information)

C12Q 1/6897 (2013.01)

Citation (search report)

See references of WO 9838336A1

Designated contracting state (EPC)

BE CH DE DK ES FI FR GB IT LI NL PT SE

EPO simple patent family

WO 9838336 A1 19980903; AU 6339098 A 19980918; CA 2279576 A1 19980903; EP 0972074 A1 20000119; IL 131336 D0 20010128; JP 2001514501 A 20010911

INPADOC legal status


2005-03-09 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20040901

2003-05-14 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20030327

2000-01-19 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19990811

2000-01-19 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): BE CH DE DK ES FI FR GB IT LI NL PT SE